高能窄带准分子光治疗白癜风的临床研究

发布时间：2018-06-24 14:40

本文选题：白癜风 + nm准分子光　；参考：《四川大学学报(医学版)》2016年04期

【摘要】：目的观察308nm高能窄带准分子光治疗白癜风的临床疗效和安全性,对影响疗效的相关因素进行评估。方法对336例白癜风患者共912处皮损进行308nm准分子光局部治疗,每周治疗1~2次。随访6个月,观察、分析色素恢复的有效率和显效率。结果 912处皮损中,出现色素恢复的显效率为44.19%(403/912),有效率为72.70%(663/912)。头面部、躯干部皮损的疗效较好,手足的疗效较差(P0.003);局限型、散在型的疗效均高于泛发型、肢端型(P0.004);皮损在进展期和稳定期的疗效相当。最初色素再生的照光次数和光的累积量为(8.48±3.31)次和(3.75±1.71)J/cm2,显效的照光次数和光的累积量分别为(15.41±2.92)次和(4.15±1.87)J/cm2。色素恢复的有效率和显效率随照光次数增多而增加。即刻不良反应表现以局部红斑62.20%(209/336)多见;随访6个月,以发生白发(31例,9.2%)和治疗中出现新发皮损或者原有皮损扩大(21例,6.2%)多见。结论 308nm高能窄带准分子光治疗白癜风疗效确切,不良反应少,患者耐受性好,是一种安全有效的方法。
[Abstract]:Objective To observe the clinical efficacy and safety of 308nm high-energy narrow band excimer light in the treatment of vitiligo, and to evaluate the related factors affecting the efficacy of vitiligo. Methods a total of 912 lesions in 336 patients with vitiligo were treated with 308nm excimer light local treatment and treated for 1~2 times a week. The results were followed up for 6 months, and the efficiency and efficiency of pigment recovery were analyzed. Results 9 Of the 12 lesions, the effective rate of pigment recovery was 44.19% (403/912), the effective rate was 72.70% (663/912). The head and face, the skin lesion of the body were better, the curative effect of the hand and foot was poor (P0.003); the therapeutic effect of the localized type was higher than that of the pan hairstyle and the acromegaly (P0.004); the skin lesion had the same effect in the progress and the stable period. The cumulative amount of light and light was (8.48 + 3.31) times and (3.75 + 1.71) J/cm2. The effective light and light accumulation were (15.41 + 2.92) times and (4.15 + 1.87) J/cm2.. The efficiency and efficiency of the pigment were increased with the increase of light times. The immediate adverse reaction was more common with local erythema 62.20% (209/336), followed up 6 months for hair. There were 31 cases of white hair (31 cases, 9.2%) and the emergence of new skin lesions or enlargement of the original skin lesions (21 cases, 6.2%). Conclusion high energy narrow band excimer light in the treatment of vitiligo is effective, less adverse reaction and good tolerance in patients. It is a safe and effective method.
【作者单位】：四川大学华西医院皮肤性病科;
【分类号】：R758.41

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