Fonsecaea monophora所致着色芽生菌病

发布时间：2018-06-26 07:18

本文选题：Fonsecaea + monophora　；参考：《临床皮肤科杂志》2017年12期

【摘要】：报告1例云贵高原地区由Fonsecaea monophora所致着色芽生菌病。患者男,38岁,农民。左小腿异物刺伤后皮肤出现丘疹、溃疡、增生伴疼痒8年。皮肤科检查:左小腿踝部至膝关节之间见大片界限清楚的红褐色斑块,边缘隆起,表面凹凸不平,呈肉芽肿样或疣状增生,并有溃疡、瘢痕形成或黄色厚痂覆盖,痂皮下有脓性或血性分泌物渗出,味腥臭。皮损组织病理:表皮假上皮瘤样增生,可见慢性肉芽肿样改变,真皮内大量中性粒细胞、淋巴细胞、浆细胞和组织细胞混合浸润,形成微脓肿,PAS染色其内可见成簇棕色厚壁孢子。取真菌培养菌落聚合酶链反应(PCR)扩增及r DNA ITS区测序鉴定为Fonsecaea monophora。诊断:Fonsecaea monophora所致着色芽生菌病。
[Abstract]:1 cases of coloring buds caused by Fonsecaea monophora were reported in Yunnan Guizhou Plateau. The patient was male, 38 years old, farmer. The skin appeared papules, ulcers, hyperplasia and itching for 8 years after the stab of the left leg foreign body. Department of Dermatology examination: the left calf ankle to the knee joints between the knee joints and the knee joints with clear reddish brown patches, the edge bulge, the surface uneven, granulation Swelling like or verrucous hyperplasia with ulcers, cicatricial formation or yellow thick scab, subcutaneous purulent or bloody secretions exudation and odor. Skin lesion histopathology: epidermis like hyperplasia of epidermis, chronic granulomatous changes, mixed infiltration of a large number of neutrophils, lymphoblastic cells, and tissue cells in the dermis, and forming a micro abscess, PA Cluster brown thick wall spores were found in S staining, and PCR amplification and R DNA ITS region sequencing were identified as Fonsecaea monophora. diagnosis: Fonsecaea monophora caused by coloring buds.
【作者单位】：深圳市宝安区人民医院皮肤科;遵义医学院附属医院皮肤科;深圳市宝安区慢性病防治院皮肤科;
【基金】：贵州省卫生计划生育委员会(gzwkj2012-1-022) 深圳市宝安区科技计划基金(2014043)资助项目
【分类号】：R756.6

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