三种抗真菌香波治疗头皮屑的疗效及作用机制探讨

发布时间：2018-07-06 08:38

本文选题：头皮屑 + 马拉色菌　；参考：《复旦大学》2010年硕士论文

【摘要】： 目的探讨三种常用洗发香波1%二硫化硒、0.5%吡罗克酮乙醇胺和1%吡硫翁锌治疗头皮屑的疗效、作用和安全性。材料与方法采用随机、双盲、阳性药物对照试验,纳入132例中、重度头皮屑患者,比较1%二硫化硒、0.5%吡罗克酮乙醇胺和1%吡硫翁锌治疗时头皮屑临床严重度评分、马拉色菌计数、相关细胞因子IL-1α/TP、IL-8/TP和TNF-α/TP的变化及其关系。结果三种香波使用过程中均无不良反应发生。在4周的治疗期后,三组头皮屑临床严重度评分和马拉色菌计数均较基线明显降低(P0.001),三组间的差异均无统计学意义。在治疗结束后的随访期各组临床严重度评分及马拉色菌计数皆有增加(P0.001),1%吡硫翁锌组临床严重度评分的增加较其余两组为重(P0.001),而马拉色菌计数的增加在三组之间无统计学差异。治疗期间细胞因子IL-1α/TP、IL-8/TP和TNF-α/TP均明显降低(P0.001)；在随访期,IL-1α/TP有显著上升(P0.05),而IL-8/TP和TNF-α/TP无明显改变,三组之间各细胞因子变化稍有不同。结论 1%二硫化硒、0.5%吡罗克酮乙醇胺和1%吡硫翁锌三种洗发香波安全性良好,对头皮屑均有较好的治疗效果,而停止使用时病情会有所恢复。三种香波对头皮屑临床严重度评分和马拉色菌的改善相似,但1%二硫化硒及0.5%吡罗克酮乙醇胺较1%吡硫翁锌对临床症状的改善更为持久。IL-1α能够较IL-8和TNF-α更灵敏地反映头皮屑严重程度变化。
[Abstract]:Objective to investigate the efficacy, effect and safety of three kinds of shampoo, 1% selenium disulfide 0.5% piroclone ethanolamine and 1% pyrithion zinc in the treatment of dandruff. Materials and methods 132 patients with severe dandruff were enrolled in a randomized, double-blind, positive drug controlled trial. The clinical severity score of dandruff, Malassezia count, IL-1 伪 / TPIL-8TP, TNF- 伪 -p-TP and TNF- 伪 -p-TP were compared between 1% selenite 0.5% piroxone ethanolamine and 1% pyrithion zinc. Results there was no adverse reaction during the use of three kinds of shampoo. After 4 weeks of treatment, the clinical severity score and Malassezia count of dandruff in the three groups were significantly lower than those in the baseline (P0.001), and there was no significant difference among the three groups. The clinical severity score and Malassezia count of each group were increased (P0.001) in the follow-up period after treatment compared with the other two groups (P0.001), but there was no significant difference between the three groups in the increase of Malassezia count. During the treatment period, the cytokines IL-1 伪 / TPt8 / TP and TNF- 伪 / TP decreased significantly (P0.001), but IL-8 / TP and TNF- 伪 / TP did not change significantly during the follow-up period (P0.05), and the changes of cytokines were slightly different among the three groups. Conclusion 1% selenite sulphide 0.5% piroxone ethanolamine and 1% pyrithion zinc shampoo are safe and effective in the treatment of dandruff. The effect of three kinds of shampoo on dandruff clinical severity score was similar to that of Malassezia. However, 1% selenium disulfide and 0.5% piroxone ethanolamine could more sensitively reflect the severity of dandruff than that of 1% zinc pyrithion. IL-1 伪 could reflect the severity of dandruff more sensitively than IL-8 and TNF- 伪.
【学位授予单位】：复旦大学
【学位级别】：硕士
【学位授予年份】：2010
【分类号】：R758.71

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