贵州兴义市麻风菌株基因分型及传播链分析

发布时间：2018-07-10 06:33

本文选题：麻风菌 + 基因分型　；参考：《中国公共卫生》2014年02期

【摘要】：目的根据麻风菌株基因型分析传播链特点。方法对2004—2009年贵州省兴义市发现的50例新发和复发麻风病患者的菌株17个串联重复序列(VNTR)位点分型,结合患者地理分布分析病例感染、传播之间的流行病学特征。结果根据AC8b、AC9、AC8a、6-7等位点基因型,兴义市流行的麻风菌有6种基因型相似的聚类株,兴义菌株在rpoT、21-3、27-5、23-3和(GGT)5位点的拷贝数完全一致,但2号和5号聚集株在12-5位点和18-8位点的拷贝数分别是4,为兴义市所特有菌株;为聚集株的26例患者中,有7例为复发病例,21例有明确的感染传播关系;1号和4号聚类株内的15例患者(57.7%)主要分布在兴义市东南部,4号聚类株为聚集在同一自然村内的布依族患者;家内患者之间感染的菌株基因型不相同。结论兴义市多种菌株与特有菌株长期共存是兴义麻风病高流行的重要因素,具有麻风易感体质的家内成员可感染周围存在的不同菌株而发病;为阻断传播,针对家内接触者和高发乡村加强发现早期病例和进行化学预防很有必要。
[Abstract]:Objective to analyze the characteristics of transmission chain according to the genotype of leprosy strain. Methods from 2004 to 2009, 17 tandem repeat (VNTR) loci of 50 new and recurrent leprosy patients in Xingyi City, Guizhou Province were classified, and the epidemiological characteristics of infection and transmission were analyzed according to the geographical distribution of the patients. Results according to the genotypes of AC8bS9 AC8aHG 6-7, there were 6 genotypic cluster strains of Leprosy bacteria in Xingyi city, and the copies of Xingyi strains were identical at the loci of rpoTt21-3, 27-5GGT and (GGT), respectively. However, the number of copies at locus 12-5 and locus 18-8 of the 2 and 5 aggregators were 4, respectively, which were endemic to Xingyi, and 26 patients with agglomeration, 15 patients (57.7%) in cluster 1 and 4 were mainly distributed in the southeast of Xingyi city, and cluster 4 were the Buyi patients who gathered in the same natural village, 7 cases were recurrent cases and 21 cases had a definite relationship of infection and transmission, and 15 cases (57.7%) in cluster 1 and 4 were mainly distributed in the southeast of Xingyi city, while cluster 4 was a group of Buyi patients in the same natural village. The genotypes of the strains infected within the home were different. Conclusion the coexistence of various strains and endemic strains in Xingyi City for a long time is an important factor in the high prevalence of leprosy in Xingyi, and the family members with leprosy susceptibility can infect different strains around them, in order to prevent the spread of leprosy. It is necessary to strengthen the detection of early cases and chemical prophylaxis for domestic contacts and high-incidence villages.
【作者单位】：贵州省疾病预防控制中心艾滋病性病皮肤病防治研究所;贵州省兴义市皮肤病性病防治站麻风防治科;首都医科大学附属北京友谊医院北京热带病研究所;
【基金】：国家自然科学基金(30670111) 美国国立卫生研究院课题(RO1-A1-63457)
【分类号】：R755

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