内皮素-1和降钙素基因相关肽与白癜风的相关性研究

发布时间：2018-07-17 02:31

【摘要】： 目的:通过检测白癜风患者血浆中内皮素-1和降钙素基因相关肽的水平变化,探讨二者与白癜风发病及病情活动的相关性,为白癜风的发病机制研究及治疗提供新的理论依据。方法:选择湖南省衡阳地区汉族人群白癜风患者60名和40名健康志愿者为研究对象,采肘静脉血5毫升,取血浆,应用ELISA法检测血浆中ET-1及CGRP的浓度。结果:1白癜风患者血浆中ET-1的浓度低于健康对照组(P0.05),进展期白癜风患者血浆中ET-1的浓度低于稳定期与健康对照组(P0.01),泛发型白癜风患者血浆中ET-1的浓度明显低于局限型与健康对照组(P0.01)。而稳定期与局限型白癜风患者血浆中ET-1的浓度与健康对照组无明显差异(P0.05)。 2白癜风患者血浆中CGRP的浓度明显高于健康对照组(P0.01),进展期白癜风患者血浆中CGRP的浓度,明显高于稳定期和健康对照组(P0.01),而泛发型白癜风患者血浆中CGRP的浓度明显高于局限型与健康对照组(P0.01)。而稳定期与局限型型白癜风患者血浆中CGRP的浓度与健康对照组无明显差异(P0.05)。 3白癜风患者组血浆中的ET-1与CGRP的浓度相关系数为-0.72(r=-0.72 p=0.002),呈负相关。进展期白癜风患者血浆中ET-1与CGRP的浓度相关系数为-0.45(r=-0.538 p=0.002),呈负相关。泛发型白癜风患者血浆中ET-1与CGRP的浓度相关系数为-0.52(r=-0.376 p=0.04),呈负相关。结论:1 ET-1和CGRP与白癜风发病有关。 2白癜风病情活动时,ET-1和CGRP呈负相关。
[Abstract]:Objective: to investigate the relationship between plasma endothelin-1 and calcitonin gene-related peptide levels in patients with vitiligo, and to provide a new theoretical basis for the study and treatment of vitiligo. Methods: 60 patients with vitiligo and 40 healthy volunteers in Hengyang area of Hunan province were selected. The plasma levels of ET-1 and CGRP were determined by Elisa. Results the concentration of ET-1 in plasma of patients with vitiligo was lower than that of healthy controls (P0.05), and that of patients with advanced vitiligo was lower than that of healthy controls (P0.01). The concentration of ET-1 in patients with generalized vitiligo was significantly lower than that in patients with generalized vitiligo (P0.01). Limited type and healthy control group (P0.01). However, there was no significant difference in plasma ET-1 levels between stable and localized vitiligo patients and healthy controls (P0.05). 2 the plasma levels of CGRP in vitiligo patients were significantly higher than those in healthy controls (P0.01), and CGRP concentrations in plasma of advanced vitiligo patients were significantly higher than those of healthy controls (P0.01). The plasma levels of CGRP in patients with generalized vitiligo were significantly higher than those in the control group (P0.01). However, there was no significant difference in plasma CGRP concentration between stable and localized vitiligo patients (P0.05). 3 the correlation coefficient between plasma ET-1 and CGRP concentration in patients with vitiligo was -0.72 (r = -0.72 p ~ (0.002), which was negatively correlated. The correlation coefficient between plasma ET-1 and CGRP in patients with vitiligo was -0.45 (r ~ (-0.538) p ~ (0.002), which was negatively correlated. The correlation coefficient between plasma ET-1 and CGRP in patients with generalized vitiligo was -0.52 (r ~ (-0.376) p ~ (0.04), which was negatively correlated. Conclusion 1 et-1 and CGRP are associated with vitiligo. 2 there is a negative correlation between et-1 and CGRP when vitiligo is active.
【学位授予单位】：南华大学
【学位级别】：硕士
【学位授予年份】：2010
【分类号】：R758.41

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