CSMD1基因多态性rs7007032与中国汉族人寻常型银屑病表型的相关性研究

发布时间：2018-07-20 09:15

【摘要】：目的探讨CSMD1基因多态性rs7007032与汉族人寻常型银屑病一些临床表型(家族史、发病年龄及皮损类型)的相关性。方法结合本课题组银屑病易感基因的全基因组关联分析数据,选取7 318例银屑病患者和11 290例正常对照的CSMD1基因多态性rs7007032基因分型资料,SPSS 16.0软件对数据资料进行统计分析,χ2检验用于比较各组间rs7007032等位基因频率分布。结果在病例组与对照组之间,CSMD1基因多态性rs7007032等位基因频率分布差异有统计学意义(P=9.24×10-9),各临床表型亚组分别与对照组比较,rs7007032等位基因频率分布差异均具有统计学意义(P1.0×10-4)。在家族史阳性和阴性患者之间、少儿发病和成人发病患者之间,rs7007032等位基因频率分布差异均有统计学意义(P0.05);在急性点滴型和慢性斑块型患者之间,rs7007032等位基因频率分布差异无统计学意义。结论 CSMD1基因多态性rs7007032与汉族人寻常型银屑病发病的易感性相关,此外还与该疾病的家族史和发病年龄相关,但与皮损的临床类型不相关。
[Abstract]:Objective to investigate the association of CSMD1 gene polymorphism rs7007032 with some clinical phenotypes (family history, age of onset and type of skin lesion) of psoriasis vulgaris in Han nationality. Methods Genome-wide association analysis data of psoriasis susceptibility genes were analyzed. The polymorphism rs7007032 genotyping data of CSMD1 gene in 7 318 patients with psoriasis and 11 290 normal controls were statistically analyzed by SPSS16.0 software. 蠂 2 test was used to compare the frequency distribution of rs7007032 alleles among groups. Results the frequency distribution of rs7007032 allele of CSMD1 gene polymorphism was significantly different between the case group and the control group (P9.24 脳 10-9). The allele frequencies of rs7007032 in each clinical phenotypic subgroup were significantly different from those in the control group (P1.0 脳 10-4). Between positive and negative family history patients, The allele frequencies of rs7007032 were significantly different between children and adults (P0.05), but there was no significant difference in the frequency distribution of rs7007032 between acute plaque patients and chronic plaque patients. Conclusion CSMD1 polymorphism rs7007032 is associated with susceptibility to psoriasis vulgaris, family history and age, but not with clinical type of skin lesions.
【作者单位】：安徽医科大学第一附属医院皮肤病研究所;皮肤病学国家重点实验室培育基地;安徽医科大学皮肤病与性病学系;
【基金】：国家自然科学基金项目(编号:30800990,81072461,31000528,30800610)
【分类号】：R758.63

【参考文献】