白癜风患者CRH、ACTH、皮质醇水平及焦虑、抑郁的相关性研究

发布时间：2018-07-20 18:13

【摘要】：目的：探讨活动期和稳定期白癜风患者下丘脑-垂体-肾上腺轴（HPA轴）神经-内分泌变化以及焦虑、抑郁情况。方法：白癜风患者50例为实验组、其中稳定期患者25例、活动期患者为25例，正常人30例对照组。测定促肾上腺皮质素释放激素(CRH)、促肾上腺皮质素(ACTH)以及皮质醇(Cortisol)水平并完成一般情况问卷和焦虑、抑郁量表测试。结果：稳定期和活动期白癜风皮质醇水平较正常人明显升高（P＜0.05），稳定期和活动期白癜风患者之间亦有明显差异（P＜0.05）、活动期皮质醇水平升高更明显。白癜风活动期组和稳定期组之间CRH,ACTH水平无明显差异(P＞0.05)。白癜风患者较正常人有明显的焦虑、抑郁症状（P＜0.05），其中活动期白癜风患者焦虑抑郁较突出、但稳定期组和活动期组之间差异无明显统计学意义(P＞0.05)。结论：白癜风患者HPA轴功能随着病情和周围环境的改变而有所变化，从而引起白癜风等各种疾病。本研究结果提示：HPA轴在白癜风发病中起重要作用，，证实了心理干预治疗在白癜风治疗中的重要意义。
[Abstract]:Objective: to investigate the neuroendocrine changes, anxiety and depression of hypothalamus-pituitary-adrenal axis (HPA axis) in active and stable vitiligo patients. Methods: fifty patients with vitiligo were divided into two groups: 25 patients in stable stage, 25 patients in active stage and 30 normal controls. The levels of corticotropin releasing hormone (CRH), adrenocorticotropic hormone (ACTH) and cortisol (Cortisol) were measured. Results: the levels of cortisol in stable and active vitiligo were significantly higher than those in normal controls (P < 0.05), and there were significant differences between stable and active vitiligo patients (P < 0.05). There was no significant difference in CRHG ACTH levels between active and stable vitiligo groups (P > 0.05). Patients with vitiligo had obvious anxiety and depression (P < 0.05), but there was no significant difference between stable group and active group (P > 0.05). Conclusion: the function of HPA axis in patients with vitiligo changes with the change of disease condition and surrounding environment, which leads to various diseases such as vitiligo. The results suggest that the weight HPA axis plays an important role in the pathogenesis of vitiligo and confirms the importance of psychological intervention in the treatment of vitiligo.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R758.41

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