清营汤加味联合阿维A治疗中、重度斑块状银屑病患者的疗效及免疫调节作用

发布时间：2018-07-28 07:35

【摘要】：目的:通过观察清营汤加味联合阿维A治疗中、重度斑块状银屑病患者的临床疗效及对细胞因子的影响,探讨其免疫调节作用。方法:选择68例斑块状银屑病患者,随机分为对照组和观察组,每组34例。两组均给予阿维A口服,观察组联合清营汤加味。疗程8周。评定比较两组治疗前后银屑病皮损面积和严重度指数(PASI)、皮肤病生活质量指数(DLQI)评分及临床有效率。测定比较两组治疗前后细胞因子IL-17、IL-22、TNF-α、IFN-γ、IL-4水平。结果:观察组的临床有效率为94.1%,显著优于对照组的76.5%(P0.05)。治疗后,两组的PASI、DLQI评分均较治疗前明显下降(P0.05),且观察组下降程度优于对照组(P0.05)。治疗后,两组的IL-17、IL-22、IFN-γ、TNF-α、IFN-γ/IL-4均较治疗前明显下降(P0.05),且观察组各指标改善程度优于对照组(P0.05)。结论:清营汤加味联合阿维A治疗中重度斑块状银屑病较单纯使用阿维A疗效更佳,能显著减轻患者临床症状,提高生活质量,其疗效机制可能与其能更好地调节Th1/Th2平衡,改善免疫功能,减轻组织的炎症损伤有关。
[Abstract]:Objective: to investigate the immunomodulatory effect of Qingying decoction combined with Avera in the treatment of severe plaque psoriasis. Methods: 68 patients with plaque psoriasis were randomly divided into control group (n = 34) and observation group (n = 34). Both groups were given Avera orally, the observation group combined with Qingying decoction. The course of treatment was 8 weeks. Before and after treatment, the area and severity of psoriasis were evaluated and compared with the (DLQI) score of skin quality of life index (DLQI) and the clinical effective rate of psoriasis. The levels of IL-17, IL-22, TNF- 伪, IFN- 纬 and IL-4 were measured before and after treatment. Results: the clinical effective rate of the observation group was 94.1%, which was significantly better than that of the control group (76.5%) (P0.05). After treatment, the PASII-DLQI scores in both groups were significantly lower than those before treatment (P0.05), and the degree of decline in the observation group was better than that in the control group (P0.05). After treatment, the levels of IL-17, IL-22, IFN- 纬, TNF- 伪, IFN- 纬 / IL-4 in the two groups were significantly lower than those before treatment (P0.05), and the improvement degree of each index in the observation group was better than that in the control group (P0.05). Conclusion: the therapeutic effect of Qingying decoction combined with Avera in treatment of moderate and severe plaque psoriasis is better than that of Avera alone. It can significantly reduce the clinical symptoms and improve the quality of life of patients. The therapeutic mechanism may be better than that of Avera in regulating the balance of Th1/Th2. Improve immune function, alleviate the inflammation of tissue injury related.
【作者单位】：武汉市武昌医院皮肤科;河北省新乐市医院皮肤科;
【基金】：河北省科技计划项目(编号:20151388)
【分类号】：R758.63

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