原发性皮肤边缘区B细胞淋巴瘤

发布时间：2018-08-06 08:06

【摘要】：报告1例原发性皮肤边缘区B细胞淋巴瘤(PCMZL)。患者男,26岁。右大腿伸侧、左肩部及左前臂各一红色或紫红色浸润性斑块,大小不等,界限清楚,表面可见米粒大丘疹,无鳞屑、破溃及压痛。皮损组织病理检查:真皮层可见淋巴样细胞弥漫或结节状浸润,少量累及表皮,浸润细胞中大量小至中等大小的中心细胞样淋巴细胞,胞质透亮,可见轻度核异形;表皮下、浸润细胞周围偶见浆细胞。免疫组化:可见大量反应性的CD3+T细胞,其周围环绕的小淋巴细胞CD20、CD79a及B细胞淋巴瘤/白血病因子(Bcl)-2均(+);肿瘤细胞增殖核抗原(Ki-67)(40%+);浆细胞限制性表达轻链-λ,不表达轻链-κ;散在肿瘤细胞CD30、CD21、CD10、Bcl-6及D型细胞周期蛋白(cyclin D)1均(+)。诊断:PCMZL。治疗:予手术切除右大腿伸侧及左肩部皮损,术后随访至今,皮损未复发及未见新发皮损。
[Abstract]:A case of primary cutaneous marginal B-cell lymphoma (PCMZL).) The patient was 26 years old. Right thigh extension, left shoulder and left forearm one red or purplish red infiltrating plaques, different size, clear boundary, rice grain papules, no scaly, crashing and tenderness. Histopathological examination of the lesions: lymphoid or nodular infiltration was seen in the dermis, a small number of infiltrating cells were found in the epidermis, a large number of small to medium sized central cell-like lymphocytes in the infiltrating cells, the cytoplasm was bright, and mild nuclear heteromorphism was observed. Plasma cells were occasionally seen around infiltrating cells. Immunohistochemistry: a large number of reactive CD3 T cells were found. The peripheral small lymphocytes CD20, CD79a and B cell lymphoma / leukemia factor (Bcl) 2 were (); tumor cell proliferative nuclear antigen (Ki-67) (40%); plasmacyte restricted expression of light chain 位, not light chain 魏; scattered in tumor cell CD30, CD21, CD10, Bcl-6 and type D cell cycle. Phase protein (cyclin D) 1 (). Diagnosis: PCMZL. Treatment: surgical excision of the right thigh extension and left shoulder skin lesions, postoperative follow-up so far, no recurrence of skin lesions and no new lesions.
【作者单位】：北京大学深圳医院皮肤性病科;
【分类号】：R739.5

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