62例银屑病住院患者回顾性临床分析
发布时间：2018-08-06 13:33
【摘要】：目的:探讨住院银屑病某些发病规律及临床特点,进而提出更合理的预防及治疗方案。 方法:通过收集汕头大学医学院第一附属医院皮肤科2003年1月——2010年12月间确诊为银屑病的62例住院患者的病历进行回顾性分析。信息包括性别、年龄、初发年龄、临床分型、伴随的疾病、既往的治疗方法、家族史、加重及诱发因素、皮损部位。χ2和T检验用于数据的统计学分析。 结果:(1)本组资料65例银屑病患者中男女比例为35:27,性别无显著性差异;银屑病患者平均初次发病年龄36.3岁,男女患者平均初次发病年龄分别为38.6岁和33.3岁;女性有两个初次发病高峰期10-20岁和50-60岁,男性初次发病高峰期为40-50岁。(2)银屑病首发、加重及复发以冬春为主,夏季病情减轻明显。(3)感染或不适当外用药物成为银屑病加重的突出因素。(4)银屑病初次发病最常见的类型为寻常型银屑病,占90.32%,脓疱型银屑和关节病型银屑病各占4.84%;复发病例中寻常型银屑病占38.71 %;脓疱型银屑病占38.71%;红皮病型银屑病占16.13%;关节病型银屑病占6.45%。(5)患者皮损的初发部位以躯干和头皮最常见。(6)患者入院前治疗中外用药主要为糖皮质激素、维生素D3衍生物及草药;系统用药主要为抗组胺药、糖皮质激素、维A酸类及中药。(7)本组资料银屑病患者伴发系统疾病者占74.19%。各类感染性疾病中病毒性肝炎占3.22%,肺部感染3.22%,泌尿系感染2.22%,疱疹病毒感染3.22%。代谢性疾病中糖尿病占6.45%,糖耐量受损14.52%,高尿酸血症6.45%,高脂血症11.29%,低蛋白血症48.39%。心脑血管疾病中高血压占11.74%,冠心病8.06%,脑卒中1.61%,各类心律失常8.06%。消化系统疾病中脂肪肝占6.45%。(8)本组资料实验室检查白细胞升高者占37.10%;血红蛋白下降占14.52%;血小板升高占22.58%.;尿常规检查尿白细胞阳性占9.68%,尿蛋白阳性占6.45%,尿潜血阳性占4.84%;谷丙转胺酶升高占12.90%,谷草转胺酶升高占27.42%。 结论:(1)银屑病的发病男女无显著性差异;(2)季节因素对银屑病的激发和加重具有重要影响;(3)银屑病与感染有关,银屑病的治疗应该注意予有效的抗感染治疗;(4)首次发病部位以躯干及头皮多见;(5)银屑病患者容易合并心血管疾病、代谢综合征等疾病,提示银屑病可能为一系统性疾病;(6)银屑病的治疗应该规律用药,避免外用刺激性强的药物。
[Abstract]:Objective: to investigate the clinical characteristics and the regularity of psoriasis in hospital, and to put forward more reasonable prevention and treatment. Methods: 62 cases of psoriasis were collected from Department of Dermatology, first affiliated Hospital of Medical College of Shantou University from January 2003 to December 2010. Information included sex, age, clinical classification, associated diseases, past treatments, family history, exacerbation and predisposing factors, site of skin lesions. 蠂 2 and T tests were used for statistical analysis of data. Results: (1) in 65 cases of psoriasis, the ratio of male and female was 35: 27, there was no significant difference in sex, the average age of first onset of psoriasis was 36.3 years old, the average age of primary onset of male and female patients was 38.6 years and 33.3 years old, respectively. There were two peak periods of onset of psoriasis in females, 10-20 years old and 50-60 years old, and 40-50 years old in males. (2) the onset of psoriasis was mainly in winter and spring. (3) infection or improper use of drugs was a prominent factor in the exacerbation of psoriasis. (4) the most common type of primary onset of psoriasis was psoriasis vulgaris. The ratio was 90.32, the pustular silver crumbs and the arthrotic psoriasis were 4.84; the recurrent cases of psoriasis vulgaris were 38.71; the pustular psoriasis was 38.71; the erythrodermic psoriasis was 16.13; the arthropathic psoriasis was 6.45; (5) the primary lesions of the patients were trunk. And scalp most commonly. (6) external use of glucocorticoids in pre-hospital treatment was mainly glucocorticoid. Vitamin D3 derivatives and herbs were mainly used as antihistamines, glucocorticoids, retinoic acids and traditional Chinese medicine. (7) patients with psoriasis accompanied with systemic diseases accounted for 74.19%. Viral hepatitis accounts for 3.22 percent of all infectious diseases, lung infection 3.22, urinary tract 2.22, herpes virus 3.22. Among metabolic diseases, diabetes accounted for 6.45%, impaired glucose tolerance 14.52%, hyperuricemia 6.45%, hyperlipidemia 11.29%, hypoproteinemia 48.39%. In cardiovascular and cerebrovascular diseases, hypertension accounts for 11.74, coronary heart disease 8.06, stroke 1.61and arrhythmia 8.06. Fatty liver accounted for 6.45% of digestive system diseases. (8) the percentage of patients with elevated white blood cells was 37.10% in the laboratory, 14.52% in hemoglobin, 22.58% in platelets, 9.68% in urine routine examination, 6.45% in urine protein, and 14.52% in urine occult blood. 4.84 the aspartate transaminase increased 12.90%, the aspartate transaminase increased 27.42%. Conclusion: (1) there is no significant difference in the incidence of psoriasis between male and female; (2) seasonal factors have an important effect on the stimulation and aggravation of psoriasis; (3) psoriasis is associated with infection. The treatment of psoriasis should be paid attention to effective anti-infective treatment; (4) the first site of the disease is the trunk and scalp; (5) Psoriasis patients are prone to be associated with cardiovascular disease, metabolic syndrome and other diseases, It suggests that psoriasis may be a systemic disease. (6) the treatment of psoriasis should be regularly used to avoid the use of stimulant drugs.
【学位授予单位】：汕头大学
【学位级别】：硕士
【学位授予年份】：2011
【分类号】：R758.63
本文编号：2167889
[Abstract]:Objective: to investigate the clinical characteristics and the regularity of psoriasis in hospital, and to put forward more reasonable prevention and treatment. Methods: 62 cases of psoriasis were collected from Department of Dermatology, first affiliated Hospital of Medical College of Shantou University from January 2003 to December 2010. Information included sex, age, clinical classification, associated diseases, past treatments, family history, exacerbation and predisposing factors, site of skin lesions. 蠂 2 and T tests were used for statistical analysis of data. Results: (1) in 65 cases of psoriasis, the ratio of male and female was 35: 27, there was no significant difference in sex, the average age of first onset of psoriasis was 36.3 years old, the average age of primary onset of male and female patients was 38.6 years and 33.3 years old, respectively. There were two peak periods of onset of psoriasis in females, 10-20 years old and 50-60 years old, and 40-50 years old in males. (2) the onset of psoriasis was mainly in winter and spring. (3) infection or improper use of drugs was a prominent factor in the exacerbation of psoriasis. (4) the most common type of primary onset of psoriasis was psoriasis vulgaris. The ratio was 90.32, the pustular silver crumbs and the arthrotic psoriasis were 4.84; the recurrent cases of psoriasis vulgaris were 38.71; the pustular psoriasis was 38.71; the erythrodermic psoriasis was 16.13; the arthropathic psoriasis was 6.45; (5) the primary lesions of the patients were trunk. And scalp most commonly. (6) external use of glucocorticoids in pre-hospital treatment was mainly glucocorticoid. Vitamin D3 derivatives and herbs were mainly used as antihistamines, glucocorticoids, retinoic acids and traditional Chinese medicine. (7) patients with psoriasis accompanied with systemic diseases accounted for 74.19%. Viral hepatitis accounts for 3.22 percent of all infectious diseases, lung infection 3.22, urinary tract 2.22, herpes virus 3.22. Among metabolic diseases, diabetes accounted for 6.45%, impaired glucose tolerance 14.52%, hyperuricemia 6.45%, hyperlipidemia 11.29%, hypoproteinemia 48.39%. In cardiovascular and cerebrovascular diseases, hypertension accounts for 11.74, coronary heart disease 8.06, stroke 1.61and arrhythmia 8.06. Fatty liver accounted for 6.45% of digestive system diseases. (8) the percentage of patients with elevated white blood cells was 37.10% in the laboratory, 14.52% in hemoglobin, 22.58% in platelets, 9.68% in urine routine examination, 6.45% in urine protein, and 14.52% in urine occult blood. 4.84 the aspartate transaminase increased 12.90%, the aspartate transaminase increased 27.42%. Conclusion: (1) there is no significant difference in the incidence of psoriasis between male and female; (2) seasonal factors have an important effect on the stimulation and aggravation of psoriasis; (3) psoriasis is associated with infection. The treatment of psoriasis should be paid attention to effective anti-infective treatment; (4) the first site of the disease is the trunk and scalp; (5) Psoriasis patients are prone to be associated with cardiovascular disease, metabolic syndrome and other diseases, It suggests that psoriasis may be a systemic disease. (6) the treatment of psoriasis should be regularly used to avoid the use of stimulant drugs.
【学位授予单位】：汕头大学
【学位级别】：硕士
【学位授予年份】：2011
【分类号】：R758.63
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相关期刊论文 前4条
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