湘西香醋体内抗氧化及其淡化黄褐斑作用的研究

发布时间：2018-08-07 07:07

【摘要】：目的:研究湘西香醋对肌肉注射黄体酮小鼠产生的黄褐斑的淡化作用,探讨其可能的机制。方法:采用肌肉注射黄体酮构造黄褐斑小鼠模型,灌胃不同剂量的湘西香醋30 d,测定小鼠肝脏和皮肤组织的MDA、NO含量、SOD活力,制作小鼠皮肤石蜡切片,观察皮肤黑色素分布情况。结果:湘西香醋具有明显的抗氧化效果,与模型组相比,香醋组小鼠的肝脏和皮肤组织MDA含量明显降低,SOD活力明显升高,NO含量明显降低,绝大多数组的差异有统计学意义(P0.05),特别是湘西香醋降低小鼠肝脏和皮肤组织MDA、皮肤组织NO含量的效果非常显著(P0.01)。饲喂香醋后,小鼠皮肤黄褐斑数量明显少于模型组,黄褐斑颜色深度也明显比模型组浅。结论:湘西香醋在小鼠体内有较强的抗氧化活性,并具有淡化黄褐斑的功效。
[Abstract]:Aim: to study the desalination effect of Xiangxi fragrant vinegar on chloasma produced by intramuscular injection of progesterone in mice and explore its possible mechanism. Methods: the mouse model of chloasma was established by intramuscular injection of progesterone. The content of MDAN and SOD in liver and skin tissue of mice were determined by intragastric administration of Xiangxi fragrant vinegar for 30 days. The paraffin sections of mouse skin were made and the distribution of melanin in skin was observed. Results: Xiangxi fragrant vinegar had obvious antioxidation effect. Compared with the model group, the content of MDA in liver and skin tissue of Xiangxi vinegar group was obviously decreased, the activity of sod was increased, and the content of no was obviously decreased. Most of the differences were statistically significant (P0.05), especially Xiangxi vinegar decreased MDAs in liver and skin tissue of mice, the effect of no content in skin tissue was very significant (P0.01). Compared with the model group, the number of chloasma and the color depth of chloasma were significantly lower in mice fed with vinegar than in the model group. Conclusion: Xiangxi vinegar has strong anti-oxidation activity in mice and can desalinate chloasma.
【作者单位】：中南林业科技大学食品科学与工程学院;稻谷及副产物深加工国家工程实验室中南林业科技大学;
【分类号】：R758.42

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