性病门诊患者1786例HPV基因亚型分析
发布时间：2018-08-11 18:30
【摘要】：目的了解性病门诊患者人乳头瘤病毒(HPV)感染情况和病毒亚型分布情况,为当地高危人群HPV感染流行病学研究和诊疗提供参考依据。方法于2012年1月-12月用PCR-反向斑点杂交法对本中心性病门诊1 786例患者进行HPV基因分型检测。结果在1 786例受检者中,男性HPV阳性检出率为47.33%,女性HPV阳性检出率为35.16%;男性感染HPV以6和11亚型为主,阳性率分别为38.42%和22.32%;而女性以HPV6,16,52和53型为主,阳性率分别为19.18%,15.89%,20.55%和16.16%;且男、女均以单一型HPV感染为主,感染率分别为67.23%和55.34%;以上差异均有统计学意义(P均0.05)。受检男性和女性感染高峰期分别为30～39岁和20～29岁。结论性病门诊男性和女性患者感染HPV主要基因亚型不同,均以单一亚型感染为主,男性常见低危HPV6和11型,女性HPV6,16,52和53型感染率最高。女性HPV感染高危患者罹患宫颈癌的风险增加,高危人群感染HPV年龄为20～40岁。
[Abstract]:Objective to investigate the prevalence of human papillomavirus (HPV) infection and the distribution of human papillomavirus (HPV) subtypes in STD outpatients in order to provide a reference for epidemiological study and diagnosis and treatment of HPV infection in high risk population. Methods from January to December, 2012, the HPV genotyping of 1 786 STD outpatients in our center was detected by PCR- reverse dot blot hybridization. Results among 1 786 subjects, the positive rate of HPV was 47.33 for males and 35.16.5 for females, 38.42% for males and 22.32% for 11 subtypes of HPV, while the positive rates were 19.1815.8920.55% and 16.1665% for females, and 16.1655% for males and 16.1655% for females, respectively. The infection rate of single type HPV was 67.23% and 55.34%, respectively, and the difference was statistically significant (P 0.05). The peak period of infection in males and females was 30 ~ 39 years old and 20 ~ 29 years old respectively. Conclusion the main gene subtypes of HPV infection in male and female patients in STD clinic were different, and most of them were infected by single subtype. The most common low risk HPV6 and 11 type were found in male, and the highest infection rate was found in female HPV6 / 1652 and 53 type. The risk of cervical cancer was increased in women with high risk of HPV infection. The age of HPV infection was 20 ~ 40 years old.
【作者单位】： 广州市皮肤病防治所;
【分类号】：R759
[Abstract]:Objective to investigate the prevalence of human papillomavirus (HPV) infection and the distribution of human papillomavirus (HPV) subtypes in STD outpatients in order to provide a reference for epidemiological study and diagnosis and treatment of HPV infection in high risk population. Methods from January to December, 2012, the HPV genotyping of 1 786 STD outpatients in our center was detected by PCR- reverse dot blot hybridization. Results among 1 786 subjects, the positive rate of HPV was 47.33 for males and 35.16.5 for females, 38.42% for males and 22.32% for 11 subtypes of HPV, while the positive rates were 19.1815.8920.55% and 16.1665% for females, and 16.1655% for males and 16.1655% for females, respectively. The infection rate of single type HPV was 67.23% and 55.34%, respectively, and the difference was statistically significant (P 0.05). The peak period of infection in males and females was 30 ~ 39 years old and 20 ~ 29 years old respectively. Conclusion the main gene subtypes of HPV infection in male and female patients in STD clinic were different, and most of them were infected by single subtype. The most common low risk HPV6 and 11 type were found in male, and the highest infection rate was found in female HPV6 / 1652 and 53 type. The risk of cervical cancer was increased in women with high risk of HPV infection. The age of HPV infection was 20 ~ 40 years old.
【作者单位】： 广州市皮肤病防治所;
【分类号】：R759
【参考文献】
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1 郑华生;郑迪楠;李剑民;林e，
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