光动力疗法治疗尿道口尖锐湿疣的临床疗效观察

发布时间：2018-08-14 17:14

【摘要】： 本研究采用先用10%ALA溶液敷药一次,30 min再用10%ALA乳膏敷药一次,3h后用635 nm的红光照射的光动力治疗方案于2008年7月至2009年3月治疗就诊于我科的108例尿道口尖锐湿疣患者,观察该方案的疗效及安全性。经1~6次治疗,108例患者中104例痊愈,痊愈率96.3%;1次治疗后痊愈率44.4%。104例患者治疗后随访12个月,共有8例(7.69%)患者复发。所有经治患者未发生系统不良反应,约半数患者光照时局部出现轻度灼伤或刺痛感,均可耐受。本研究方案与液氮、电离子、CO2激光以及外用细胞毒性药物、免疫调节剂相比具有疗效好、不良反应小、复发率低的优点;与国内外已报道的单纯外用ALA溶液或单纯外用ALA乳膏的方案比较具有操作简便、敷药时间短等优势,具有临床应用价值。
[Abstract]:From July 2008 to March 2009, 108 patients with condyloma acuminatum of urethral orifice were treated with 10%ALA solution for 30 min and 10%ALA cream for 3 h, followed by 635nm red light irradiation, from July 2008 to March 2009, in our department, 108 patients with condyloma acuminatum of urethral orifice were treated. To observe the efficacy and safety of the regimen. 104 of 108 patients were cured after 1 and 6 times of treatment, and the cure rate was 96. 3%. The recovery rate was 44. 4%. 104 cases were followed up for 12 months after treatment. There were 8 cases (7. 69%) relapsed. There were no systemic adverse reactions in all the patients, and about half of the patients had mild burns or tingling during illumination, which could be tolerated. Compared with liquid nitrogen, electric ion CO _ 2 laser and external cytotoxic drugs, this scheme has the advantages of better curative effect, less adverse reaction and lower recurrence rate. Compared with ALA solution or ALA cream reported at home and abroad, it has the advantages of simple operation, short application time, and has clinical application value.
【学位授予单位】：吉林大学
【学位级别】：硕士
【学位授予年份】：2010
【分类号】：R752.53

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