特比萘芬口服联合萘替芬酮康唑乳膏治疗手足癣84例临床观察

发布时间：2018-08-24 10:44

【摘要】：目的评价口服特比萘芬联合萘替芬酮康唑乳膏治疗手足癣的临床疗效和安全性。方法将入选的168例手足癣患者随机分成两组,各84例。对照组予口服特比萘芬250mg,1次/d,治疗组在对照组治疗方案的基础上予萘替芬酮康唑乳膏外搽,2~4次/d。两组患者的疗程均为1个月。结果治疗组治疗第1,2,3和4周末的有效率分别为22.62%,51.19%,80.95%和92.86%;对照组分别为14.29%,44.05%,67.86%和70.24%。有效率差异有统计学意义(P0.05)。两组不良反应均未予特殊处理,不影响治疗。结论口服特比萘芬联合萘替芬酮康唑乳膏治疗手足癣的临床疗效显著,不良反应小,值得临床选择应用。
[Abstract]:Objective to evaluate the efficacy and safety of terbinafine combined with ketoconazole cream in the treatment of tinea pedis. Methods 168 patients with tinea pedis were randomly divided into two groups, 84 cases in each group. The control group was given oral terbinafine 250 mg / d, and the treatment group was given nafenaphthene ketoconazole ointment 2 times / d 4 times per day on the basis of the control group's treatment plan. The course of treatment was 1 month in both groups. Results the effective rates of the treatment group at the end of the 1st week and the 4th week were 22.622.19% and 92.86%, respectively, while that of the control group were 14.292.05% and 70.24%, respectively. The difference of effective rate was statistically significant (P0.05). The adverse reactions in both groups were not specially treated and did not affect the treatment. Conclusion Oral terbinafine combined with natifen ketoconazole cream is effective in the treatment of tinea pedis.
【作者单位】： 山东省枣庄市皮肤病性病防治院;
【分类号】：R756.3

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