Livin和Smac在日光性角化病中的表达及意义

发布时间：2018-09-05 10:52

【摘要】：目的探讨凋亡抑制蛋白Livin(活素)和促凋亡因子Smac(第二个线粒体衍生的半胱氨酸蛋白酶激活剂)在日光性角化病(AK)中的表达及意义。方法应用免疫组化SP法检测76例AK组织中Livin和Smac的表达,分析二者表达的相关性。结果 Livin在AK组织中的阳性表达率为55.26%,在正常对照组为3.33%,二者比较差异有统计学意义(P0.001)。Livin在不同病理亚型AK(肥厚型、萎缩型、苔藓样型和鲍恩样型)中的阳性表达率分别为52.00%,52.94%,45.45%和72.73%,各组之间比较差异无统计学意义。Smac在AK组织中的阳性表达率为56.58%,在正常对照组为100.00%,二者比较差异有统计学意义(P0.001)。Smac在不同病理亚型AK(肥厚型、萎缩型、苔藓样型和鲍恩样型)中的阳性表达率分别为56.00%,64.71%,63.64%和45.45%,各组之间比较差异无统计学意义。Livin和Smac在AK中的表达呈负相关(r=-0.468,P0.01)。结论肥厚型、萎缩型、苔藓样型和鲍恩样型AK中Livin和Smac的表达与病理亚型无关,Livin的过表达和Smac的低表达可能在AK的发生、发展中起一定作用。
[Abstract]:Objective to investigate the expression and significance of apoptosis inhibitor (Livin) and apoptosis-promoting factor Smac (the second mitochondrial derived cysteine protease activator) in (AK) of sunlight keratosis. Methods the expression of Livin and Smac in 76 cases of AK was detected by immunohistochemical SP method and the correlation between them was analyzed. Results the positive expression rate of Livin in AK tissue was 55.26 and 3.33 in normal control group. The difference was statistically significant (P0.001) .Livin in different pathological subtypes of AK (hypertrophic type, atrophy type). The positive expression rates of moss-like type and Bao En type were 52.00% and 72.73%, respectively. There was no significant difference between the two groups. The positive expression rate of Smac in AK tissues was 56.58 and that in the normal control group was 100.000.The difference between the two groups was statistically significant. Smac (P0. 001) in different pathological subtypes of AK (hypertrophic type, P0. 001) The positive expression rates of atrophy type, moss-like type and Bao En type were 56.00% and 45.4545%, respectively. There was no significant difference in the expression of Livin and Smac in AK (r-0.468, P0.01). Conclusion the expression of Livin and Smac in hypertrophic, atrophic, moss-like and Bao En like AK is not related to the overexpression of livin and the low expression of Smac in the pathological subtypes, which may play a role in the pathogenesis and development of AK.
【作者单位】：青岛市市立医院皮肤科;青岛市市立医院病理科;
【分类号】：R758.1

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