钙泊三醇倍他米松软膏和地塞米松霜治疗稳定期寻常性银屑病的自身对照研究

发布时间：2018-09-08 11:25

【摘要】：目的:比较钙泊三醇倍他米松软膏和地塞米松霜外用治疗稳定期寻常性银屑病患者临床疗效和安全性的差异。方法:自身左右对照临床试验研究。入组30例皮损面积30%休表面积的稳定期寻常性银屑病患者,均有左右侧对称皮损。随机纳入试验组或对照组。试验侧晚间外用1次钙泊三醇倍他米松软膏,对照侧晚间外用1次0.1%地塞米松霜,疗程4周。于用药后第1、2、4周观察临床疗效及安全性。结果:治疗1、2、4周后试验侧靶皮损瘙痒、红斑、浸润、鳞屑单独积分均较治疗前有所下降,4周时积分较基线时的下降比率分别为91.76%、74.26%、91.84%和87.36%,均大于对照侧(分别为69.05%、45%、41.24%和47.67%),两组差异有统计学意义(P0.01),治疗4周时试验侧靶皮损瘙痒、红斑、浸润、鳞屑总积分较基线时的下降比率为85.98%,大于对照侧(54.77%),两组差异有统计学意义(x2=47.60,P0.01)。药物不良反应轻微,主要为与皮肤有关的轻中度反应如瘙痒、毛囊炎等,大多数都能耐受。结论:钙泊三醇倍他米松软膏治疗稳定期寻常性银屑病患者起效快、疗效好,且用药方便、相对安全。
[Abstract]:Objective: to compare the clinical efficacy and safety of calcium betamethasone ointment and dexamethasone cream in the treatment of stable psoriasis vulgaris. Methods: a controlled clinical trial was conducted. 30 patients with stable psoriasis with 30% surface area of skin lesions had symmetrical lesions on the left and right sides. They were randomly included in the experimental group or the control group. The experimental side was treated with calcium potriol betamethasone ointment once at night and the control side with 0.1% dexamethasone cream for 4 weeks. The clinical efficacy and safety were observed 4 weeks after treatment. Results: after 4 weeks of treatment, the target lesion of the experimental side was itchy, erythema and infiltrated. The decrease rates of scaly scores were 91.76% 74.26% and 87.36 6% respectively, which were higher than those of the control side (69.05% 41.24% and 47.67%, respectively). The difference between the two groups was statistically significant (P0.01). At 4 weeks after treatment, the skin lesions of the experimental targets were pruritus, erythema, and macula, and the difference between the two groups was statistically significant (P0.01), and the difference between the two groups was statistically significant (P0.01), and the difference between the two groups was statistically significant (P0.01), and the difference between the two groups was significant (P0.01). The decrease rate of the total scale integral was 85.98, which was higher than that of the control side (54.77%), and the difference between the two groups was statistically significant (x2 + 47.60 卤P0.01). Adverse drug reactions are mild, mainly skin-related mild to moderate reactions such as pruritus, folliculitis, and most can tolerate. Conclusion: calcipotriol betamethasone ointment is effective and safe in the treatment of stable psoriasis vulgaris.
【作者单位】：镇江市疾病预防控制中心;
【分类号】：R758.63

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