IL-20在扁平苔藓发病及恶化过程中的意义
发布时间：2018-09-08 12:12
【摘要】：扁平苔藓（Lichen planus，LP）为一种临床常见的慢性或亚急性炎症性皮肤疾病，但是目前对该病的研究并不充分，特别是对其发病机制以及在恶化过程中的相关因素研究较少。一般多认为LP为自身免疫性疾病，因此，本研究通过对患者IL-20在患者患病及治疗过程中的表达,以确认IL-20这种免疫因子对于LP进展中的影响。 目的：分析扁平苔藓发病过程中，IL-20在患者外周血表达水平变化特点，为该病的发病机理及进展期治疗提供有力的支持，从而完善该病的治疗体系。同时，为进一步的确定该病的发病机制提供有力的临床依据。 方法：回顾性分析本院门诊和住院的30例临床确诊为LP的患者的临床治疗情况，其中，有10例患者经过临床治疗，，LP的症状明显减轻，另有10例患者并无明显的改善，另有10例患者，症状呈明显的恶化趋势。为考察上述患者治疗过程中的免疫学表达特点，以ELISA试剂盒测定患者外周者血的IL-20的浓度。并进行统计学分析，以确定IL-20在患者体内外周血表达水平及其相关性。 结果：通过对患者的IL-20在患者体内外周血表达水平及其变化特点可知，全部30例患者在治疗初期IL-20的表达情况均明显高于正常人外周血。并且，通过一个治疗周期后发现，LP症状减轻的患者，其IL-20的表达有显著性下降，但是仍然高于正常人外周血；LP症状恶化的患者，其IL-20的表达并无显著变化，该结果表明， IL-20在患者发生扁平苔藓的过程中，起到了显著性的作用。但是，在进一步恶化过程中，IL-20并非主要因素。 结论：IL-20在患者LP发病过程中起到了显著性作用，此参数的提高可以大大增加患者LP发病的风险；而在进一步的恶化过程中， IL-20的影响并不大，LP症状减轻的患者，其IL-20的表达有显著性下降。从而确定，IL-20同患者的发病关系非常密切。
[Abstract]:Lichen planus (Lichen planus,LP) is a common chronic or subacute inflammatory skin disease, but it is not well studied at present, especially on its pathogenesis and related factors in the process of deterioration. LP is generally considered to be an autoimmune disease. Therefore, the expression of IL-20 in patients during the course of disease and treatment was studied in order to confirm the influence of IL-20, an immune factor, on the progression of LP. Objective: to analyze the changes of IL-20 expression in peripheral blood of patients with lichen planus (Lichen planus), and to provide strong support for the pathogenesis and advanced treatment of Lichen planus, so as to improve the therapeutic system of Lichen planus. At the same time, to further determine the pathogenesis of the disease to provide a strong clinical basis. Methods: the clinical treatment of 30 patients with LP was analyzed retrospectively. Among them, 10 patients with LP were obviously relieved after clinical treatment, and 10 patients had no significant improvement. In the other 10 patients, the symptoms showed an obvious trend of deterioration. In order to investigate the immunological expression characteristics of the patients, the concentration of IL-20 in peripheral blood was measured by ELISA kit. Statistical analysis was carried out to determine the expression of IL-20 in peripheral blood of patients and its correlation. Results: the expression of IL-20 in peripheral blood of all 30 patients was significantly higher than that of normal controls at the beginning of treatment. After a treatment cycle, the expression of IL-20 in patients with mild LP symptoms was significantly decreased, but the expression of IL-20 was still higher than that in patients with normal peripheral blood and LP symptoms, and there was no significant change in the expression of IL-20. The results suggest that IL-20 plays a significant role in the development of lichen planus. However, IL-20 is not a major factor in the process of further deterioration. ConclusionTwo -IL-20 plays a significant role in the pathogenesis of LP, and the increase of this parameter can greatly increase the risk of LP, but in the process of further deterioration, the effect of IL-20 is not significant in patients with lessening of LP symptoms. The expression of IL-20 decreased significantly. Thus it is determined that IL-20 is closely related to the onset of the disease.
【学位授予单位】：吉林大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R758.65
本文编号：2230482
[Abstract]:Lichen planus (Lichen planus,LP) is a common chronic or subacute inflammatory skin disease, but it is not well studied at present, especially on its pathogenesis and related factors in the process of deterioration. LP is generally considered to be an autoimmune disease. Therefore, the expression of IL-20 in patients during the course of disease and treatment was studied in order to confirm the influence of IL-20, an immune factor, on the progression of LP. Objective: to analyze the changes of IL-20 expression in peripheral blood of patients with lichen planus (Lichen planus), and to provide strong support for the pathogenesis and advanced treatment of Lichen planus, so as to improve the therapeutic system of Lichen planus. At the same time, to further determine the pathogenesis of the disease to provide a strong clinical basis. Methods: the clinical treatment of 30 patients with LP was analyzed retrospectively. Among them, 10 patients with LP were obviously relieved after clinical treatment, and 10 patients had no significant improvement. In the other 10 patients, the symptoms showed an obvious trend of deterioration. In order to investigate the immunological expression characteristics of the patients, the concentration of IL-20 in peripheral blood was measured by ELISA kit. Statistical analysis was carried out to determine the expression of IL-20 in peripheral blood of patients and its correlation. Results: the expression of IL-20 in peripheral blood of all 30 patients was significantly higher than that of normal controls at the beginning of treatment. After a treatment cycle, the expression of IL-20 in patients with mild LP symptoms was significantly decreased, but the expression of IL-20 was still higher than that in patients with normal peripheral blood and LP symptoms, and there was no significant change in the expression of IL-20. The results suggest that IL-20 plays a significant role in the development of lichen planus. However, IL-20 is not a major factor in the process of further deterioration. ConclusionTwo -IL-20 plays a significant role in the pathogenesis of LP, and the increase of this parameter can greatly increase the risk of LP, but in the process of further deterioration, the effect of IL-20 is not significant in patients with lessening of LP symptoms. The expression of IL-20 decreased significantly. Thus it is determined that IL-20 is closely related to the onset of the disease.
【学位授予单位】：吉林大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R758.65
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