延边地区儿童AD患者血清总IgE和sIgE水平及过敏原的研究

发布时间：2018-09-14 17:47

【摘要】： 目的：在延边大学附属医院皮肤科门诊就诊的小儿特应性皮炎(atopic dermatitis, AD)患者,通过观察血清总IgE水平和过敏原特异性IgE抗体以及过敏原的调查研究,为预防和诊治延边地区小儿AD提供可靠的科学依据。 方法：本研究中所用资料均来自2006年3月到2009年3月到延边大学附属医院皮肤科门诊就诊并确定为AD的患者,共200例。分为两个组,即婴幼儿组和小儿组,每组100例,每组又按民族分为朝汉两个小组,每组各50例。同时选择38例正常体检小儿为对照组。用敏筛定量过敏原检测系统,定量检测血清中总IgE和过敏原特异性IgE抗体。所有数据均用SPSS.10.0统计学软件进行统计学处理。结果：(1)在200例被检患者中,血清总IgE水平超过正常值上线100IU/ml的有114例(57%)。(2)在200例被检患者中血清特异性IgE阳性111例(55.5%)。(3)在200例被检患者中血清特异性IgE阳性111例中只对1种过敏原发生阳性反应的有50例(25%),对2种过敏原呈阳性反应39例(19.5%),对2种以上过敏原呈阳性反应22例(11%)。(4)在200例被检患者中血清特异性IgE只有吸入组呈阳性反应的有43例(21.5%)。(5)在200例被检患者中血清特异性IgE只有食入组呈阳性反应的有46例(23%)。(6)在200例被检患者中血清特异性IgE吸入、食入组均呈阳性反应的有23例(11.5%)。(7)在200例被检患者中阳性率较高的特异性过敏原依次为牛奶45(22.5%)、牛肉羊肉39(19.5%)、户尘螨粉尘螨35(17.5%)、鱼虾蟹16(8.0%)。(8)从年龄上看,婴幼儿组的100例中阳性率较高的特异性过敏原依次为牛奶24(24%),牛肉羊肉20(20%),户尘螨粉尘螨19(19%),小麦9(9%),小儿组的100例中阳性率较高的特异性过敏原依次为牛奶21(21%),牛肉羊肉19(19%),户尘螨粉尘螨16(16%),点青霉分枝孢霉烟曲霉交链孢霉11(11%)。 结论：(1)AD患者有IgE合成增加。(2)AD患者为多种抗原过敏。(3)延边地区小儿AD患者阳性率较高的特异性过敏原依次为牛奶、牛肉羊肉、户尘螨粉尘螨、鱼虾蟹。(4)朝鲜族与汉族AD患者总IgE值及特异性IgE检测,无显著差异。
[Abstract]:Objective: To investigate the serum total IgE level, allergen specific IgE antibody and allergen in children with atopic dermatitis (AD) in the dermatology outpatient department of Yanbian University Affiliated Hospital, and to provide reliable scientific basis for the prevention and treatment of AD in Yanbian area.
Methods: The data used in this study were from the dermatology outpatient clinic of Yanbian University Affiliated Hospital from March 2006 to March 2009, 200 cases were divided into two groups: infant group and children group, 100 cases in each group, 50 cases in each group according to nationality. All the data were analyzed by SPSS.10.0 statistical software. Results: (1) Among 200 patients, 114 (57%) had serum total IgE levels exceeding 100 IU/ml of the normal value. Of the 200 patients examined, only 50 (25%) had positive reactions to one allergen, 39 (19.5%) had positive reactions to two allergens, and 22 (11%) had positive reactions to more than two allergens. 43 (21.5%) of the inhalation group were positive. (5) Of the 200 patients examined, only 46 (23%) were positive for serum specific IgE in the ingestion group. (6) Serum specific IgE was inhaled in 200 patients and 23 (11.5%) were positive in the ingestion group. (7) Specific allergens with high positive rates were found in 200 patients. Milk 45% (22.5%), beef and mutton 39% (19.5%), house dust mite 35% (17.5%) and fish, shrimp and crab 16% (8.0%). (8) From the age point of view, the specific allergens with higher positive rate in 100 cases of infant group were milk 24% (24%), beef and mutton 20% (20%), house dust mite 19% (19%) and wheat 9% (9%). The allergens were milk 21% (21%), beef and mutton 19% (19%), house dust mite 16% (16%) and Penicillium fumigatus 11% (11%).
Conclusion: (1) AD patients have increased IgE synthesis. (2) AD patients are allergic to a variety of antigens. (3) The higher positive rate of specific allergens in children with AD in Yanbian is milk, beef and mutton, household dust mites, dust mites, fish, shrimp and crabs. (4) There is no significant difference in total IgE value and specific IgE detection between Korean and Han AD patients.
【学位授予单位】：延边大学
【学位级别】：硕士
【学位授予年份】：2010
【分类号】：R758.2

【参考文献】

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