盐酸非索非那定片不同应用方案在慢性自发性荨麻疹患者中的效果对比

发布时间：2018-10-16 09:14

【摘要】：目的比较盐酸非索非那定片不同应用方案在慢性自发性荨麻疹(CSU)患者中的效果。方法选取2013年6月至2016年的3月在海口市第三人民医院皮肤科门诊就诊的92例CSU患者为研究对象,分为观察组与对照组,各46例。对照组给予常规恒定剂量方案,口服盐酸非索非那定片120mg/d,连续12周,观察组给予逐步减量方案,前4周、第5~8周和第9~12周的剂量分别为120、90、60mg/d,具体实施方案根据患者症状的控制状况进行调整。比较两组的基线资料、服药量及治疗前后的症状积分、皮肤病生活质量指数(DLQI)总分。结果两组的基线资料、治疗前的症状积分与DLQI总分比较,差异无统计学意义(P0.05),具有可比性。在治疗第8、12周结束时,观察组中分别有34例(73.9%)、29例(63.0%)患者根据减量方案仍能完全控制症状。观察组患者第5~8、9~12周的服药量低于对照组,差异有统计学意义(P0.05)。两组的治疗后的症状积分与DLQI总分比较,差异无统计学意义(P0.05)。结论 CSU患者在服用盐酸非索非那定片120mg/d治疗4周后可考虑开始逐渐减低剂量,其能取到恒定剂量方案类似的疗效。
[Abstract]:Objective to compare the efficacy of fexofenadine hydrochloride in patients with chronic spontaneous urticaria (CSU). Methods from June 2013 to March 2016, 92 patients with CSU were selected from Department of Dermatology, third people's Hospital of Haikou City as study objects, divided into observation group (n = 46) and control group (n = 46). The control group was given a routine constant dose regimen, oral fexofenadine hydrochloride 120 mg / d for 12 consecutive weeks, the observation group was given a gradual reduction regimen, the first 4 weeks, The dose of 60mg / d at the 8th week and the 12th week was 120,90g / d, respectively, which was adjusted according to the condition of the patient's symptom control. Baseline data, drug dosage, symptom score and total score of quality of life index (DLQI) before and after treatment were compared between the two groups. Results there was no significant difference between the baseline data of the two groups before treatment and the total score of DLQI (P0.05). At the end of the 12th week of treatment, there were 34 cases (73.9%) in the observation group and 29 cases (63.0%) in the observation group. The dosage of the observation group was lower than that of the control group at the 12th week (P0.05). There was no significant difference between the symptom score and the total score of DLQI after treatment between the two groups (P0.05). Conclusion after 4 weeks of treatment with fexofenadine hydrochloride 120mg/d, patients with CSU can begin to reduce the dose gradually, which can obtain a similar therapeutic effect with a constant dose regimen.
【作者单位】：海南省海口市第三人民医院皮肤科;海口市人民医院博爱社区卫生服务中心;海南省文昌市皮肤性病防治中心;
【分类号】：R758.24

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