130例大疱性类天疱疮患者系统性疾病发生情况分析

发布时间：2018-10-16 12:27

【摘要】：目的:分析130例大疱性类天疱疮(BP)住院患者神经系统疾病、糖尿病、高血压、冠心病、心律失常及慢性肾功能衰竭等系统性疾病的发生情况及危险因素分析。方法:对130例BP住院患者(BP组)及130例同期年龄及性别相匹配的其他皮肤病患者(对照组)的临床资料进行回顾性病例对照分析。并将系统性疾病作为变量进行单因素和多因素Logistic回归分析。结果:BP组中神经系统疾病主要为脑卒中、痴呆、帕金森病和癫痫。单因素分析显示脑卒中(30%)和痴呆(6.1%)的发生率高于对照组,两组差异有统计学意义(P=0.001,P=0.042)。多因素Logistic回归分析显示脑卒中是BP的独立危险因素[OR=2.722,95%CI(1.436~5.160),P=0.002]。BP组中糖尿病、心律失常、慢性肾功能衰竭、高血压及慢性阻塞性肺疾病的发生率均高于对照组,但差异无统计学意义(P0.05)。恶性肿瘤在BP组的发生率低于对照组,两者差异无统计学意义(P0.05)。结论:脑卒中与BP具有相关性。采用多专科合作的综合管理措施,对优化BP的治疗有重要意义。
[Abstract]:Objective: to analyze the incidence and risk factors of systemic diseases such as nervous system disease, diabetes mellitus, hypertension, coronary heart disease, arrhythmia and chronic renal failure in 130 patients with bullous pemphigoid (BP). Methods: the clinical data of 130 BP inpatients (BP group) and 130 age and sex matched dermatosis patients (control group) were analyzed retrospectively. Univariate and multivariate Logistic regression analysis was performed with systemic disease as a variable. Results: the main neurological diseases in BP group were stroke, dementia, Parkinson's disease and epilepsy. Univariate analysis showed that the incidence of stroke (30%) and dementia (6.1%) was significantly higher than that of the control group (P0. 001). Multivariate Logistic regression analysis showed that stroke was an independent risk factor for BP [OR=2.722,95%CI (1.436 卤5.160), P0. 002] .The incidence of diabetes, arrhythmia, chronic renal failure, hypertension and chronic obstructive pulmonary disease in BP group was higher than that in control group, but there was no significant difference (P0.05). The incidence of malignant tumor in BP group was lower than that in control group, there was no significant difference between them (P0.05). Conclusion: stroke is associated with BP. It is of great significance to optimize the treatment of BP by adopting the comprehensive management measures of multi-specialty cooperation.
【作者单位】：沈阳市第七人民医院皮肤科;
【分类号】：R758.66

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