蜂房退疣饮联合艾拉光动力治疗扁平疣的疗效观察及对T细胞亚群的影响
发布时间：2018-10-21 13:38
【摘要】：目的：观察蜂房退疣饮联合氨基酮戊酸光动力（ALA-PDT)疗法治疗扁平疣的临床疗效及对患者T细胞亚群的影响。 方法：将43例扁平疣患者随机分成2组，治疗组22例，内服蜂房退疣饮联合ALA-PDT治疗；对照组21例，单纯应用ALA-PDT治疗。每周复诊1次，为1疗程，皮疹未消退者再行下1疗程治疗。疗程4周，，观察两组的临床疗效及不良反应，同时观察比较3个月后两组复发率及治疗前后患者T细胞亚群水平的变化。 结果：临床疗效：两组总有效率均为100%；治愈率治疗组为90.91%，对照组为85.71%，治疗组治愈率略高于对照组，差异无统计学意义（P0.05）；治疗组治疗次数少于对照组，差异有统计学意义（P0.05）；3个月后随访，治疗组复发率低于对照组，差异有统计学意义（P0.05）。实验室检测：治疗前，两组CD8~+水平均高于正常对照组，CD4~+、CD4~+/CD8~+均低于正常对照组（P0.05）；治疗后，治疗组CD8~+水平有明显下降，CD4~+、 CD4~+/CD8~+水平有明显上升，均有统计学意义（P0.05）；对照组治疗前后血清CD4~+、CD8~+、CD4~+/CD8~+水平未见明显变化（P㧐0.05）；治疗后二组比较，治疗组CD8~+水平低于对照组，CD4~+、CD4~+/CD8~+水平高于对照组，差异有统计学意义（P㩳0.05）。 结论：蜂房退疣饮联合ALA-PDT治疗扁平疣的临床疗效确切，可以明显缩短治疗疗程，降低复发率，其作用机理可能与调整体内T细胞亚群水平有关。
[Abstract]:Objective: to observe the clinical effect and the effect on T cell subsets of patients with verruca plana treated by Bei Fang Tuiyou Yin and Aminolevulinic Acid photodynamic (ALA-PDT). Methods: Forty-three patients with verruca plana were randomly divided into two groups: the treatment group (n = 22), treated with hive verruca decoction and ALA-PDT, and the control group (n = 21, treated with ALA-PDT alone). Return visit once a week for a course of treatment, rash did not subside the next course of treatment. After 4 weeks of treatment, the clinical efficacy and adverse reactions of the two groups were observed, and the changes of the recurrence rate and the T cell subsets before and after treatment in the two groups were observed and compared at the same time. Results: the total effective rate of the two groups was 100. The cure rate was 90.91 in the treatment group and 85.71 in the control group. The cure rate in the treatment group was slightly higher than that in the control group, the difference was not statistically significant (P0.05), the number of times of treatment in the treatment group was less than that in the control group, and the difference was statistically significant (P0.05). After 3 months follow-up, the recurrence rate in the treatment group was lower than that in the control group, the difference was statistically significant (P0.05). Laboratory test: before treatment, the levels of CD8~ in the two groups were higher than those in the normal control group, CD4~, CD4~ / CD8~ were lower than those in the normal control group (P0.05), after treatment, the CD8~ level in the treatment group was significantly decreased, the CD4~, CD4~ / CD8~ levels were significantly increased (P0.05), and the levels of CD4~ and CD4~ / CD8~ in the treatment group were significantly higher than those in the control group (P0.05). The levels of serum CD4~, CD8~, CD4~ / CD8~ in the control group were not significantly changed before and after treatment, and the levels of CD8~, CD4~ and CD4~ / CD8~ in the treatment group were lower than those in the control group (P0. 05). Conclusion: the clinical curative effect of honeycomb Tuiyou decoction combined with ALA-PDT in the treatment of verruca plana is definite, which can shorten the course of treatment and reduce the recurrence rate. The mechanism may be related to adjusting the level of T cell subsets in vivo.
【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R752.52
[Abstract]:Objective: to observe the clinical effect and the effect on T cell subsets of patients with verruca plana treated by Bei Fang Tuiyou Yin and Aminolevulinic Acid photodynamic (ALA-PDT). Methods: Forty-three patients with verruca plana were randomly divided into two groups: the treatment group (n = 22), treated with hive verruca decoction and ALA-PDT, and the control group (n = 21, treated with ALA-PDT alone). Return visit once a week for a course of treatment, rash did not subside the next course of treatment. After 4 weeks of treatment, the clinical efficacy and adverse reactions of the two groups were observed, and the changes of the recurrence rate and the T cell subsets before and after treatment in the two groups were observed and compared at the same time. Results: the total effective rate of the two groups was 100. The cure rate was 90.91 in the treatment group and 85.71 in the control group. The cure rate in the treatment group was slightly higher than that in the control group, the difference was not statistically significant (P0.05), the number of times of treatment in the treatment group was less than that in the control group, and the difference was statistically significant (P0.05). After 3 months follow-up, the recurrence rate in the treatment group was lower than that in the control group, the difference was statistically significant (P0.05). Laboratory test: before treatment, the levels of CD8~ in the two groups were higher than those in the normal control group, CD4~, CD4~ / CD8~ were lower than those in the normal control group (P0.05), after treatment, the CD8~ level in the treatment group was significantly decreased, the CD4~, CD4~ / CD8~ levels were significantly increased (P0.05), and the levels of CD4~ and CD4~ / CD8~ in the treatment group were significantly higher than those in the control group (P0.05). The levels of serum CD4~, CD8~, CD4~ / CD8~ in the control group were not significantly changed before and after treatment, and the levels of CD8~, CD4~ and CD4~ / CD8~ in the treatment group were lower than those in the control group (P0. 05). Conclusion: the clinical curative effect of honeycomb Tuiyou decoction combined with ALA-PDT in the treatment of verruca plana is definite, which can shorten the course of treatment and reduce the recurrence rate. The mechanism may be related to adjusting the level of T cell subsets in vivo.
【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R752.52
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