异维A酸联合阿奇霉素治疗青春期后中重度痤疮的临床研究
发布时间：2018-10-22 16:32
【摘要】：目的观察异维A酸联合阿奇霉素对青春期后中重度痤疮的临床疗效和安全性,以及其对患者体内性激素水平的影响。方法将120例患者随机分为对照组60例和试验组60例。对照组予以局部外敷0.1%阿达帕林凝胶均匀涂抹患处(睡前清洗创面后敷用),qd,共4周。试验组在对照组的基础上,予以口服异维A酸胶囊,每次10 mg,qd+阿奇霉素颗粒,饭后2小时口服,每次0.2 g,qd(服3 d停4 d),共4周。比较2组患者临床疗效、疗效指数及对血清睾酮、雌二醇、孕酮、催乳素(PRL)、促卵泡激素(FSH)、黄体生成素(LH)、性激素结合蛋白(SHBG)、硫酸脱氢表雄酮(DHEAS)的差异。结果治疗后,试验组和对照组的总有效率分别为96.67%(58/60例)和73.33%(44/60例),差异有统计学意义(P0.01)。试验组和对照组的疗效指数分别是79.68±11.34和53.46±14.17,差异有统计学意义(P0.01)。治疗后,试验组和对照组的血清雌二醇分别为(43.15±14.91),(35.87±18.43)pg·mL~(-1);FSH分别为(9.23±1.29),(8.95±2.21)mU·mL~(-1);LH分别为(7.81±0.32),(5.63±0.73)mU·mL~(-1);LH/FSH分别为0.86±0.28和0.73±0.31;睾酮分别为(1.27±0.06),(2.58±0.11)nmol·L~(-1);孕酮分别为(0.95±0.12),(1.19±0.23)ng·mL~(-1);PRL分别为(10.31±1.17),(14.53±1.09)ng·mL~(-1);SHBG分别为(51.32±18.71),(69.93±13.65)nmol·L~(-1);DHEAS分别为(169.85±28.41),(183.24±29.18)μg·dL~(-1),差异均有统计学意义(均P0.05)。试验组和对照组的药物不良反应主要有红斑、脱屑、灼热、瘙痒及干燥等症状,药物不良反应发生率分别为23.33%(14/60例)和18.33%(11/60例),差异无统计学意义(P0.05)。结论异维A酸与阿奇霉素联合用药有良好的治疗效果,可以有效地降低体内性激素水平,缩短治疗的时间。
[Abstract]:Objective to observe the clinical efficacy and safety of isotinic acid combined with azithromycin in the treatment of moderate and severe postpubertal acne and the effect of isotinic acid combined with azithromycin on sex hormone levels in patients. Methods 120 patients were randomly divided into control group (n = 60) and experimental group (n = 60). In the control group, 0.1% adalin-gel was applied to the affected area (after cleaning the wound before bedtime,), qd, was applied for 4 weeks). On the basis of the control group, the experimental group was given isotinic acid capsules, 10 mg,qd azithromycin granules, 2 hours after meals, 0.2 g / g QD (3 days and 4 d),) for 4 weeks. The clinical efficacy, efficacy index, serum testosterone, estradiol, progesterone, prolactin (PRL), follicle stimulating hormone (FSH), luteinizing hormone (LH),) -binding protein (SHBG), (SHBG),) and dehydroepiandrosterone (DHEAS) (DHEAS) were compared between the two groups. Results after treatment, the total effective rates of the experimental group and the control group were 96.67% (58 / 60 cases) and 73.33% (44 / 60 cases), respectively. The difference was statistically significant (P0.01). The curative index of the experimental group and the control group were 79.68 卤11.34 and 53.46 卤14.17, respectively. The difference was statistically significant (P0.01). 娌荤枟鍚，
本文编号：2287697
[Abstract]:Objective to observe the clinical efficacy and safety of isotinic acid combined with azithromycin in the treatment of moderate and severe postpubertal acne and the effect of isotinic acid combined with azithromycin on sex hormone levels in patients. Methods 120 patients were randomly divided into control group (n = 60) and experimental group (n = 60). In the control group, 0.1% adalin-gel was applied to the affected area (after cleaning the wound before bedtime,), qd, was applied for 4 weeks). On the basis of the control group, the experimental group was given isotinic acid capsules, 10 mg,qd azithromycin granules, 2 hours after meals, 0.2 g / g QD (3 days and 4 d),) for 4 weeks. The clinical efficacy, efficacy index, serum testosterone, estradiol, progesterone, prolactin (PRL), follicle stimulating hormone (FSH), luteinizing hormone (LH),) -binding protein (SHBG), (SHBG),) and dehydroepiandrosterone (DHEAS) (DHEAS) were compared between the two groups. Results after treatment, the total effective rates of the experimental group and the control group were 96.67% (58 / 60 cases) and 73.33% (44 / 60 cases), respectively. The difference was statistically significant (P0.01). The curative index of the experimental group and the control group were 79.68 卤11.34 and 53.46 卤14.17, respectively. The difference was statistically significant (P0.01). 娌荤枟鍚，
本文编号：2287697
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