白芍总苷联合窄谱中波紫外线及卡泊三醇治疗中度寻常性银屑病78例疗效分析

发布时间：2018-10-26 08:09

【摘要】：目的观察白芍总苷(total glucosides of paeony,TGP)联合窄谱中波紫外线(narrow band ultraviolet B light,NB-UVB)、卡泊三醇治疗中度寻常性银屑病的临床疗效和安全性。方法 154例中度寻常性银屑病患者随机分为治疗组78例和对照组76例。两组给予NB-UVB每周3次照射和卡泊三醇乳膏每日2次外用治疗,此外,治疗组给与白芍总苷胶囊600mg口服,3次/d。两组疗程均为8周。以银屑病皮损面积和严重程度(PASI)评分评价疗效并记录不良反应。结果治疗8周后,治疗组PASI评分(2.1±0.8)低于对照组(5.3±1.4),差异有统计学意义(P0.05);治疗组有效率(88.46%)高于对照组(73.68%),差异有统计学意义(P0.05)。两组未见明显不良反应。结论 TGP联合NB-UVB、卡泊三醇治疗中度寻常性银屑病疗效好,安全性高。
[Abstract]:Objective to observe the clinical efficacy and safety of carpotriol combined with total glucoside of paeony (total glucosides of paeony,TGP) combined with narrow band ultraviolet B (narrow band ultraviolet B light,NB-UVB) in the treatment of moderate psoriasis vulgaris. Methods 154 patients with moderate psoriasis vulgaris were randomly divided into treatment group (n = 78) and control group (n = 76). The two groups were treated with NB-UVB three times a week and carpotriol cream twice a day. In addition, the treatment group was treated with 600mg, three times a day. The course of treatment was 8 weeks in both groups. The (PASI) score of psoriasis lesion area and severity was used to evaluate the curative effect and to record adverse reactions. Results after 8 weeks of treatment, the PASI score of the treatment group (2.1 卤0.8) was significantly lower than that of the control group (5.3 卤1.4) (P0.05). The effective rate of the treatment group (88.46%) was higher than that of the control group (73.68%), the difference was statistically significant (P0.05). No obvious adverse reactions were observed in the two groups. Conclusion TGP combined with NB-UVB, carpotriol is effective and safe in the treatment of moderate psoriasis vulgaris.
【作者单位】：兰州军区兰州总医院皮肤科;兰州市第一人民医院皮肤科;
【基金】：2012年兰州市科技发展指导性计划项目(2012-ZD-11)
【分类号】：R758.63

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