润燥止痒胶囊联合卤米松治疗原发性皮肤淀粉样变病68例疗效观察

发布时间：2018-11-20 08:01

【摘要】：目的探讨润燥止痒胶囊口服联合卤米松软膏局部外用治疗原发性皮肤淀粉样变病的临床疗效及安全性。方法将就诊于门诊的129例原发性皮肤淀粉样变病患者随机分为治疗组及对照组,其中治疗组68例给予润燥止痒胶囊口服及卤米松软膏局部外用;对照组61例,仅给予卤米松外用治疗。分别在治疗第2,4和8周末时进行症状评分、疗效判定和安全性评价。结果在治疗的第2周末时,治疗组和对照组有效率分别为47.06%和45.90%,两组差异无统计学意义(P0.05);在治疗的第4和第8周末时,治疗组有效率为69.12%和83.82%,对照组为55.74%和62.30%,两组差异均有统计学意义(P0.05)。两组患者仅有轻微不良反应。结论润燥止痒胶囊口服联合卤米松软膏局部外用治疗原发性皮肤淀粉样变病临床疗效较好,中长期使用(1~2个月)疗效优于单用卤米松治疗,且不良反应轻微。
[Abstract]:Objective to investigate the clinical efficacy and safety of Runzao Zhiyang capsule combined with halomethasone ointment in the treatment of primary cutaneous amyloidosis. Methods 129 patients with primary cutaneous amyloidosis were randomly divided into treatment group and control group. 68 patients in treatment group were given Runzao Zhiyang capsule and halomisone ointment for topical use. The control group (61 cases) was treated with halomethasone for external use only. Symptom scores, efficacy and safety were evaluated at the end of the 4th and 8th week of treatment. Results at the end of the second week of treatment, the effective rates of the treatment group and the control group were 47.06% and 45.90%, respectively. There was no significant difference between the two groups (P0.05). At the end of the 4th and 8th week, the effective rate of the treatment group was 69.12% and 83.82%, the control group was 55.74% and 62.30%, the difference between the two groups was statistically significant (P0.05). There were only minor adverse reactions in both groups. Conclusion the clinical efficacy of Runzao Zhiyang capsule combined with halomethasone ointment in treating primary cutaneous amyloidosis is better than that of halomethasone alone in the long term (1 ~ 2 months), and the adverse reaction is slight.
【作者单位】：西宁市第二人民医院;
【分类号】：R758.6

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