单纯疱疹病毒2型感染与缺血性脑卒中不良预后的关系
发布时间：2018-11-20 15:08
【摘要】：目的探讨单纯疱疹病毒2型(herpes simplex virus 2,HSV-2)感染与缺血性脑卒中发病后14 d(或出院)时不良预后的关系。方法 2011年6月~2013年12月,本研究采用队列研究的方法,从国内14家医院纳入确诊的缺血性脑卒中病例1 150例,检测入院时血清HSV-2 Ig G水平,以发病后14 d(或出院)发生死亡或心血管事件为不良预后,采用Logistic回归方法分析HSV-2 Ig G水平与不良预后的关系。结果依HSV-2 Ig G四分位数将病例分为4组,以第1分位组为参照组,经多因素调整后第4分位组发生不良预后的风险是参照组的4.32倍(95%CI:1.33~14.03,P=0.015),且随不同组间HSV-2 Ig G水平的增加,不良预后的发生风险有增加的趋势。亚组分析发现,病例为女性、或不饮酒、或伴有糖尿病、或伴有高血压时,高水平HSV-2 Ig G可增加14 d(或出院)时不良预后的发生风险(均有P0.05)。结论缺血性脑卒中伴HSV-2感染时,高水平的HSV-2 Ig G能增加病后14 d(或出院)时不良预后的发生风险,且随HSV-2 Ig G水平的增加,不良预后的发生风险有增加的趋势。
[Abstract]:Objective to investigate the relationship between herpes simplex virus 2 (HSV-2) infection and poor prognosis at 14 days after ischemic stroke. Methods from June 2011 to December 2013, a cohort study was conducted in 1 150 patients with ischemic stroke from 14 hospitals in China. Serum HSV-2 Ig G levels were measured at admission. Taking death or cardiovascular events 14 days after onset or discharge as the adverse prognosis, the relationship between HSV-2 Ig G level and adverse prognosis was analyzed by Logistic regression method. Results the patients were divided into 4 groups according to the HSV-2 Ig G quartile. The risk of adverse prognosis in the 4th quartile group after multivariate adjustment was 4.32 times higher than that in the control group (95 CI: 1.3314.03 P 0.015). The risk of adverse prognosis increased with the increase of HSV-2 Ig G level in different groups. Subgroup analysis showed that high level of HSV-2 Ig G increased the risk of adverse prognosis at 14 d (or discharge) in female patients who did not drink alcohol or had diabetes mellitus or hypertension (P0.05). Conclusion in ischemic stroke with HSV-2 infection, the high level of HSV-2 Ig G can increase the risk of adverse prognosis 14 days after the disease (or discharge), and with the increase of HSV-2 Ig G level, the risk of adverse prognosis increased.
【作者单位】： 苏州大学医学部公共卫生学院流行病与卫生统计学系;常州市武进区湖塘镇鸣凰社区卫生服务中心防保科;内蒙古兴安盟人民医院检验科;苏州市立医院科教科;辽宁省阜新市中心医院神经科;
【基金】：国家自然科学基金(81172760)
【分类号】：R743.3;R752.11
本文编号：2345235
[Abstract]:Objective to investigate the relationship between herpes simplex virus 2 (HSV-2) infection and poor prognosis at 14 days after ischemic stroke. Methods from June 2011 to December 2013, a cohort study was conducted in 1 150 patients with ischemic stroke from 14 hospitals in China. Serum HSV-2 Ig G levels were measured at admission. Taking death or cardiovascular events 14 days after onset or discharge as the adverse prognosis, the relationship between HSV-2 Ig G level and adverse prognosis was analyzed by Logistic regression method. Results the patients were divided into 4 groups according to the HSV-2 Ig G quartile. The risk of adverse prognosis in the 4th quartile group after multivariate adjustment was 4.32 times higher than that in the control group (95 CI: 1.3314.03 P 0.015). The risk of adverse prognosis increased with the increase of HSV-2 Ig G level in different groups. Subgroup analysis showed that high level of HSV-2 Ig G increased the risk of adverse prognosis at 14 d (or discharge) in female patients who did not drink alcohol or had diabetes mellitus or hypertension (P0.05). Conclusion in ischemic stroke with HSV-2 infection, the high level of HSV-2 Ig G can increase the risk of adverse prognosis 14 days after the disease (or discharge), and with the increase of HSV-2 Ig G level, the risk of adverse prognosis increased.
【作者单位】： 苏州大学医学部公共卫生学院流行病与卫生统计学系;常州市武进区湖塘镇鸣凰社区卫生服务中心防保科;内蒙古兴安盟人民医院检验科;苏州市立医院科教科;辽宁省阜新市中心医院神经科;
【基金】：国家自然科学基金(81172760)
【分类号】：R743.3;R752.11
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