大疱性类天疱疮一例报道并文献复习
发布时间：2019-01-10 07:37
【摘要】：目的 分析大疱性类天疱疮的临床表现、诊断标准、鉴别诊断及辅助检查特征,提高对该病的认识,减少临床误诊率及漏诊率。方法 回顾性分析1例诊断为大疱性类天疱疮患者的临床资料,并结合国内外相关的文献,对大疱性类天疱疮特征性临床表现、诊断、鉴别诊断等进行讨论。结果 患者男性,56岁,全身红斑、水疱,瘙痒2月余。尼氏征阴性,全身散在分布红斑,张力性水疱、大疱,部分糜烂,表面血痂。辅助检查结果显示：血常规：WBC 8.14×109/L, HGB 132g/L, RBC 4.05×1012/L。尿常规：GLU(3+)组织病理：符合大疱性类天疱疮。诊断：大疱性类天疱疮。治疗以系统应用糖皮质激素为主联合免疫抑制剂,治疗有效。结论 大疱性类天疱疮是一种表皮下大疱性皮肤病,常见于老年人,张力性水疱位于正常或炎症性皮肤上,免疫病理学检查在表皮基底膜带有IgG和C3线状沉积为特点。其需要与天疱疮、获得性大疱性表皮松解症、疱疹样皮炎和大疱性红斑狼疮等疾病鉴别。对于明确大疱性类天疱疮的患者,要通过临床症状、组织病理学、免疫学等各项辅助检查评估疾病的损害程度,做到早发现、早诊断、早治疗,最大程度降低机体的损伤。
[Abstract]:Objective to analyze the clinical manifestations, diagnostic criteria, differential diagnosis and auxiliary examination features of bullous pemphigoid, to improve the understanding of the disease and to reduce the rate of clinical misdiagnosis and missed diagnosis. Methods the clinical data of a patient with bullous pemphigoid were analyzed retrospectively, and the clinical features, diagnosis and differential diagnosis of bullous pemphigoid were discussed. Results the patient, 56 years old, had erythema, blister and itching for more than 2 months. Nissl's sign negative, the whole body scattered erythema, tension blister, bullous, partial erosion, surface blood scab. The results of auxiliary examination showed that WBC 8.14 脳 109 / L, HGB 132g / L, RBC 4.05 脳 1012 / L, blood routine: WBC 8.14 脳 10 9 / L, HGB 132 g / L, RBC 4.05 脳 10 12 / L. Urine routine: GLU (3) histopathology: in accordance with bullous pemphigoid. Diagnosis: bullous pemphigoid. The therapy is based on the systematic application of glucocorticoid and immunosuppressant. Conclusion bullous pemphigoid is a kind of subepidermal bullous dermatosis, which is common in the elderly. The tensional blister is located on the normal or inflammatory skin, and the immunopathology is characterized by IgG and C3 linear deposition in the epidermal basement membrane. It needs to be distinguished from pemphigus, acquired bullous epidermolysis, herpes dermatitis and bullous lupus erythematosus. For the patients with bullous pemphigoid, the degree of damage should be evaluated by clinical symptoms, histopathology, immunology and other auxiliary examinations, so as to make early detection, early diagnosis, early treatment, and minimize the damage of the body.
【学位授予单位】：山东大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R758.66
本文编号：2406058
[Abstract]:Objective to analyze the clinical manifestations, diagnostic criteria, differential diagnosis and auxiliary examination features of bullous pemphigoid, to improve the understanding of the disease and to reduce the rate of clinical misdiagnosis and missed diagnosis. Methods the clinical data of a patient with bullous pemphigoid were analyzed retrospectively, and the clinical features, diagnosis and differential diagnosis of bullous pemphigoid were discussed. Results the patient, 56 years old, had erythema, blister and itching for more than 2 months. Nissl's sign negative, the whole body scattered erythema, tension blister, bullous, partial erosion, surface blood scab. The results of auxiliary examination showed that WBC 8.14 脳 109 / L, HGB 132g / L, RBC 4.05 脳 1012 / L, blood routine: WBC 8.14 脳 10 9 / L, HGB 132 g / L, RBC 4.05 脳 10 12 / L. Urine routine: GLU (3) histopathology: in accordance with bullous pemphigoid. Diagnosis: bullous pemphigoid. The therapy is based on the systematic application of glucocorticoid and immunosuppressant. Conclusion bullous pemphigoid is a kind of subepidermal bullous dermatosis, which is common in the elderly. The tensional blister is located on the normal or inflammatory skin, and the immunopathology is characterized by IgG and C3 linear deposition in the epidermal basement membrane. It needs to be distinguished from pemphigus, acquired bullous epidermolysis, herpes dermatitis and bullous lupus erythematosus. For the patients with bullous pemphigoid, the degree of damage should be evaluated by clinical symptoms, histopathology, immunology and other auxiliary examinations, so as to make early detection, early diagnosis, early treatment, and minimize the damage of the body.
【学位授予单位】：山东大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R758.66
【参考文献】
相关期刊论文 前1条
1 李妍;王娣;陈喜雪;钟珊;邱于芳;赵俊郁;朱学骏;;BP180NC16a与大疱性类天疱疮病情变化的关系[J];中国皮肤性病学杂志;2009年06期
，本文编号：2406058
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