微管不稳定蛋白stathmin在炎症性皮肤病引起的慢性瘙痒患者中的作用

发布时间：2019-03-19 15:44

【摘要】：目的:研究微管不稳定蛋白stathmin在炎症性皮肤病引起的慢性瘙痒患者发病机制中的作用。方法:收集35例炎症性皮肤病引起的慢性瘙痒患者的皮损标本和3例正常人的皮肤标本。用免疫组化(immunohistochemistry,IHC)法检测皮肤活检标本中stathmin的表达。用苏木精-伊红染色(hematoxylin-eosinstaining,HE染色)检测患者表皮组织中病理结构的变化。结果:IHC法检测结果显示,与正常对照的皮肤相比,stathmin在患者皮损中表皮角质形成细胞、毛囊上皮细胞和免疫炎症细胞中高表达。HE染色显示慢性瘙痒患者皮损处增厚、角化过度,并伴有炎症性细胞浸润。结论:研究结果初步表明stathmin在慢性瘙痒的机制中发挥作用。Stathmin通过在角质形成细胞、上皮细胞和免疫炎症细胞中的表达影响皮肤屏障功能,促进慢性瘙痒的进程。Stathmin可能是慢性瘙痒治疗的新靶点,对慢性瘙痒的治疗和新药研发具有重要意义。
[Abstract]:Aim: to study the role of microtubule unstable protein (stathmin) in the pathogenesis of chronic pruritus induced by inflammatory dermatosis. Methods: the skin lesions of 35 patients with chronic pruritus caused by inflammatory dermatosis and 3 normal skin specimens were collected. Immunohistochemical (immunohistochemistry,IHC) method was used to detect the expression of stathmin in skin biopsy specimens. Hematoxylin-eosin staining (hematoxylin-eosinstaining,HE) was used to detect the pathological changes in the epidermis of the patients. Results: the results of IHC assay showed that stathmin was highly expressed in keratinocytes, hair follicle epithelial cells and immune inflammatory cells in the lesions of patients with chronic pruritus compared with the normal skin. He staining showed that the lesions of patients with chronic pruritus were thickened. Hyperkeratosis is associated with inflammatory cell infiltration. Conclusion: the results suggest that stathmin plays a role in the mechanism of chronic pruritus. Stathmin affects skin barrier function through the expression of stathmin in keratinocytes, epithelial cells and immune inflammatory cells. Stathmin may be a new target for the treatment of chronic pruritus, which is of great significance to the treatment of chronic pruritus and the development of new drugs.
【作者单位】：重庆医科大学神经科学中心;重庆医科大学附属第一医院皮肤科;重庆医科大学附属第一医院内分泌乳腺外科;
【基金】：重庆市研究生科研创新资助项目(编号:CYS15138)
【分类号】：R751

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