中药汤剂联合小剂量雷公藤和阿维A胶囊治疗中重度银屑病疗效观察

发布时间：2019-03-26 11:15

【摘要】：目的：采用中药协定2号、5号方(即导师协定凉血解毒及益气活血方)联合小量阿维A或雷公藤治疗116例中、重度银屑病,观察该方案的临床实际疗效,不仅为临床医治此病提供新的方案,更为推广中医药及中、西医联合治疗提供依据。方法：收入来自中国医学科学院皮肤病研究所门诊、且符合纳入及排除标准的116例银屑病患者,依据非随机对照原则,分成两组。血瘀病患57例,予益气活血方(党参12g、黄芪30g、桂枝8g、干姜3g、厚朴12g、苦杏仁l0g、苍耳子l0g、白鲜皮15g、防风l0g、阿胶9g、黄连3g、白术12g、甘草2g、大枣3g)及小量阿维A 1Omg qd；血热病患59例,予凉血解毒汤(蒲公英12g、地丁草12g、连翘12g、银花12g、蛇舌草15g、玄参10g、苦杏仁12g、黄芪12g、桑白皮12g、茵陈12g、地骨皮12g、夏枯草10g、甘草3g、浙贝10g、、桃仁12g)及微量雷公藤片33ug qd。依上述医治手段,一个月为一疗程,观察三个月。结果： 1.益气活血汤联合1Omg阿维A治疗血瘀证型中重度银屑病患者57例,总有效率91.23%,凉血解毒汤联合33ug雷公藤治疗血热证型中重度银屑病患者59例,总有效率89.83%。2.完成实验共计116位病患,11例痊愈,42例显效,52例有效,余11例无效,总有效率90.52%。仅3例病患因用药引发一过性肝酶略高,余未见不良副反应。结论：益气活血汤、凉血解毒汤(即协定5号、2号方)联合小量阿维A或雷公藤医治中重度寻常型银屑病,疗效较佳,运用安全性相对较高,病患配合良好。
[Abstract]:Objective: to observe the clinical efficacy of treatment of 116 cases of moderate and severe psoriasis with herbal medicine agreement no. 2 and no. 5 (namely tutor agreement cool blood detoxification and Yiqi Huoxue recipe) combined with a small dose of Avira or Tripterygium wilfordii in the treatment of 116 cases of moderate and severe psoriasis. It not only provides a new scheme for clinical treatment of this disease, but also provides a basis for the promotion of Chinese medicine and Chinese and western medicine combined treatment. Methods: 116 patients with psoriasis who met the criteria of inclusion and exclusion were divided into two groups according to the principle of non-randomized control according to the income from the outpatient department of the Institute of Dermatology, Chinese Academy of Medical Sciences. 57 patients with blood stasis were treated with Yiqi Huoxue recipe (Codonopsis 12 g, Astragalus membranaceus 30 g, Guizhi 8 g, dry ginger 3 g, Magnolia officinalis 12 g, bitter almond 10 g, Xanthium sibiricum 10 g, white fresh skin 15 g, Fangfeng 10 g, A Jiao 9 g, Coptis chinensis 3 g, Baizhu 12 g, Glycyrrhiza uralensis 2g, Jujube (3G) and small amount of A 1Omg qd; 59 patients with blood fever were treated with Liangxue jiedu decoction (dandelion 12g, Didi grass 12g, forsythia 12g, honeysuckle 12g, Hedyotis officinalis 15g, Xuanshen 10g, bitter almonds 12g, Astragalus membranaceus 12g, mulberry bark 12g, Yinchen 12g, ground bone skin 12g, summer withered grass 10g, licorice 3g, Zhejiang shellfish 10g, , peach kernel 12g) and trace tripterygium wilfordii tablet 33ug qd. According to the above treatment, a month as a course of treatment, observation for three months. Results: 1. 57 patients with moderate or severe psoriasis of blood stasis syndrome were treated with Yiqi Huoxue decoction combined with 1Omg A, the total effective rate was 91.23%, and 59 patients with moderate and severe psoriasis of blood heat syndrome type were treated with Liangxue jiedu decoction combined with 33ug. The total effective rate was 89.83%. Of 116 patients, 11 cases were cured, 42 cases were effective, 52 cases were effective, and the remaining 11 cases were ineffective. The total effective rate was 90.52%. Only 3 patients had a slightly higher level of primary hepatic enzymes due to the use of drugs, and no side effects were found in the rest of the patients. Conclusion: Yiqi Huoxue decoction, Liangxue jiedu decoction (Ava or Tripterygium wilfordii) combined with Yiqi Huoxue decoction, combined with Avian or Tripterygium wilfordii in the treatment of moderate and severe psoriasis vulgaris has better curative effect, relatively high safety and good coordination between patients and patients.
【学位授予单位】：南京中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R758.63

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