退银汤联合NB-UVB治疗寻常性银屑病的临床研究

发布时间：2019-04-01 14:48

【摘要】：目的探讨退银汤内服联合窄谱中波紫外线(NB-UVB)局部照射治疗寻常性银屑病的临床疗效和安全性。方法将129例寻常性银屑病患者随机分为3组,每组43例。联合治疗组内服退银汤,2次/d,予以NB-UVB局部照射,初始剂量为0.5J·cm-2,2次/周,每次递增剂量10%~20%,至出现红斑时维持治疗;对照Ⅰ组单纯内服退银汤;对照Ⅱ组单纯使用NBUVB局部照射,方法均同治疗组,三组均连续治疗12周。分别于治疗前和治疗后第4、8、12周记录PSAI评分,同时评价临床疗效。结果联合治疗组、对照Ⅰ组、对照Ⅱ组治疗前PSAI评分分别为(17.46±4.87)、(16.77±5.05)、(17.14±4.92),治疗组与对照Ⅰ组、对照Ⅱ组比较,差异均无统计学意义(P0.05);治疗后PSAI评分分别为(4.31±1.12)、(7.11±2.47)、(8.05±2.66),治疗组与对照Ⅰ组、对照Ⅱ组比较,差异均有统计学意义(P0.01);治疗组、对照Ⅰ组、对照Ⅱ组有效率分别为95.3%、72.1%、67.4%,治疗组与对照Ⅰ组、对照Ⅱ组比较,差异均有统计学意义(P0.01);治疗组、对照Ⅰ组、对照Ⅱ组不良反应发生率分别为14.0%、7.0%、16.3%,三组比较差异均无统计学意义(P0.05)。结论退银汤内服联合NB-UVB局部照射治疗寻常性银屑病疗效确切,安全性好,值得皮肤科临床推广使用。
[Abstract]:Objective to investigate the clinical efficacy and safety of Huayin decoction combined with narrow-spectrum ultraviolet B (NB-UVB) in the treatment of psoriasis vulgaris. Methods 129 patients with psoriasis vulgaris were randomly divided into 3 groups with 43 patients in each group. The patients in the combined treatment group were treated with NB-UVB local irradiation twice a day, the initial dose was 0.5J / cm-2,2 / week, the increasing dose was 10% ~ 20%, and the patients in control group 鈪，

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