综合疗法对于结节性痒疹患者生活质量及人血清P物质的影响

发布时间：2019-05-15 23:40

【摘要】：目的探讨综合疗法对于结节性痒疹湿毒瘀结证患者生活质量的影响及与人血清P物质水平的关系。方法选择160例结节性痒疹湿毒瘀结证患者,随机分为综合治疗组、西药组、中药组、外用药组,每组40例。均15d为1个疗程,共用4个疗程,随访半年观察复发情况。根据皮肤病生活质量指数(DLQI)、临床疗效、汉密顿抑郁量表(HAMD)及焦虑量表(HAMA)评定综合疗法对患者生活质量的影响程度;以双抗夹心ELISA方法来评定药物对P物质的影响及其相关性。结果综合治疗组疗效明显优于其他三组,明显改善了患者的生活质量并大大降低了P物质浓度,且与P物质水平呈正相关。结论综合疗法效果明显优于其余三组,改善了患者的生活质量,与P物质水平的变化可能有关联。
[Abstract]:Objective to investigate the effect of comprehensive therapy on quality of life (QOL) in patients with nodular prurigo dampness, poison and blood stasis syndrome and its relationship with human serum substance P level. Methods 160 patients with dampness, poison and blood stasis syndrome of nodular itching were randomly divided into comprehensive treatment group, western medicine group, traditional Chinese medicine group and external drug group with 40 cases in each group. All of them were 15 days as a course of treatment, a total of 4 courses of treatment, followed up for half a year to observe the recurrence. According to the clinical efficacy of skin disease quality of life index (DLQI), Hamilton depression scale (HAMD) and anxiety scale (HAMA) were used to evaluate the influence of comprehensive therapy on quality of life (QOL). The effect of drugs on substance P and its correlation were evaluated by double antibody sandwich ELISA. Results the curative effect of the comprehensive treatment group was significantly better than that of the other three groups, which significantly improved the quality of life of the patients and greatly reduced the concentration of substance P, which was positively correlated with the level of substance P. Conclusion the effect of comprehensive therapy is obviously better than that of the other three groups, and the quality of life of the patients is improved, which may be related to the change of substance P level.
【作者单位】：河北省衡水市第四人民医院皮肤科;
【分类号】：R758.6

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