PTTG1基因多态性rs2431697与汉族人寻常型银屑病表型的相关性研究

发布时间：2019-06-05 02:34

【摘要】：目的探讨垂体瘤转化基因(PTTG1)基因多态性rs2431697与汉族人寻常型银屑病临床表型(有无家族史、发病年龄、皮损类型)的相关性。方法选取5 468例银屑病患者和6 406例正常对照的PTTG1基因多态性rs2431697的基因分型资料(基因分型采用Illumina 610芯片)。比较各组间等位基因和基因型频率的分布。结果 rs2431697等位基因和基因型频率分布在病例组和对照组间差异有显著性(P1.0×10-3);有、无家族史患者间等位基因频率分布差异有显著性(P=0.02),而基因型频率分布差异无显著性;在少儿发病患者和成人发病患者,慢性斑块型患者和急性点滴型患者之间差异无显著性。结论 PTTG1基因多态性rs2431697与汉族人寻常型银屑病易感性有关,特别是与家族性银屑病相关性更为明显,但与发病年龄、皮损类型可能无关。
[Abstract]:Objective to investigate the relationship between pituitary adenoma transforming gene (PTTG1) gene polymorphism rs2431697 and clinical phenotype (family history, age of onset, skin lesion type) of psoriasis vulgaris in Han nationality. Methods the genotyping data of PTTG1 gene polymorphism rs2431697 from 5468 psoriatic patients and 6406 normal controls were selected (Illumina 610 chip). The distribution of allelic and genotypic frequencies in each group was compared. Results there was significant difference in the frequency distribution of rs2431697 allele and genotype between the case group and the control group (P1.0 脳 10 脳 3). Yes, there was significant difference in the frequency distribution of alleles among patients without family history (P 鈮，

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