7年间郑州市某院住院患者药疹发生率和相关危险因素分析

发布时间：2019-06-10 23:32

【摘要】：目的探讨近7年来本院住院患者中药疹发生率的变化特点及相关危险因素。方法回顾性分析本院2006年1月-2012年12月的143 262例住院患者,其中出现皮疹并请皮肤科医师会诊明确的280例药疹患者,详细分折药疹的逐年发生率的变化、引起药疹的药物分类以及药疹发生科室的特点。结果280例药疹患者的平均年龄为(37.23±15.68)岁。2006-2012年药疹发生率(‰)分别为1.04,1.17,1.61,2.41,2.59,2.68,1.95,2012年药疹发生率下降。致敏药物中抗生素类占40.35%、解热镇痛药及非甾体抗炎药物占14.29%、抗癫痫类药物占12.50%、中药制剂占12.14%、生物制品占10.71%。内科系统药疹发生数明显高于外科系统,以神经内科最多(17.50%),分科药疹发生率以呼吸内科最高(5.56%)。结论 2012年抗生素引起的药疹发生率下降。但是抗生素、解热镇痛药及非甾体抗炎药物引起药疹仍位居第一和第二。中药制剂、生物制品引起的药疹逐年升高,应引起临床医生足够重视。
[Abstract]:Objective to investigate the characteristics and related risk factors of the incidence of traditional Chinese medicine rash in inpatients in our hospital in recent 7 years. Methods 143262 hospitalized patients from January 2006 to December 2012 were analyzed retrospectively. among them, 280 patients with drug rash were consulted by dermatologists. The annual incidence of drug rash was divided into two groups. The classification of drugs causing drug eruption and the characteristics of drug eruption department. Results the average age of 280 patients with drug eruption was (37.23 卤15.68) years old. The incidence of drug eruption from 2006 to 2012 was 1.04, 1.17, 1.61, 2.41, 2.59, 2.68, 1.95, respectively, and the incidence of drug eruption decreased in 2012. Among the sensitizing drugs, antibiotics accounted for 43.5%, antipyretic and analgesic drugs and non-steroidal anti-inflammatory drugs accounted for 14.29%, antiepileptic drugs accounted for 12.50%, traditional Chinese medicine preparations accounted for 12.14%, and biological products accounted for 10.71%. The incidence of drug eruption in internal medicine system was significantly higher than that in surgical system, especially in neurology department (17.50%) and respiratory department (5.56%). Conclusion the incidence of drug rash caused by antibiotics decreased in 2012. However, antibiotics, antipyretic and analgesic drugs and non-steroidal anti-inflammatory drugs still ranked first and second. The rash caused by traditional Chinese medicine preparation and biological products is increasing year by year, which should be paid enough attention by clinicians.
【作者单位】：郑州大学第五附属医院医院皮肤性病科;
【分类号】：R758.25

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