卡介菌多糖核酸联合特异性脱敏对特应性皮炎患者血清IL-2与IL-4水平的影响

发布时间：2019-06-19 14:57

【摘要】：目的探讨卡介菌多糖核酸联合特异性脱敏治疗对特应性皮炎患者IL-2与IL-4表达的影响。方法选择35例特应性皮炎患者作为治疗组,同时选择32名本单位健康职工作为正常对照组。治疗组患者应用卡介菌多糖核酸治疗共半年,同时采用阿罗格行脱敏治疗并持续至1年,采用放射免疫法测定对照组人群和治疗前后患者血清总IgE,IL-2和IL-4水平。结果特应性皮炎患者治疗前血清IL-4水平(5.11±1.47)μg/L和IgE水平(8.93±3.15)U/mL明显高于正常对照组(3.32±1.08)μg/L和(1.66±1.56)U/mL(P0.01),治疗前患者IL-2水平(2.16±0.97)μg/L明显低于对照组(5.60±1.49)μg/L,差异有统计学意义(P0.01);治疗1年后血清IL-2水平(4.51±1.76)μg/L较治疗前显著升高,而治疗后IL-4和IgE水平(3.32±1.08)μg/L和(4.62±2.15)U/mL较之治疗前明显降低,差异均有统计学意义(P0.01)。相关性分析表明,血清IL-2水平与SCORAD得分呈显著负相关(P0.01);而血清IL-4水平与SCORAD得分呈显著正相关(P0.01)。结论卡介菌多糖核酸联合特异性脱敏可通过调控Th1/Th2细胞因子之间的平衡用以治疗特应性皮炎患者。
[Abstract]:Objective to investigate the effect of BCG polysaccharide nucleic acid combined with specific desensitization on the expression of IL-2 and IL-4 in patients with atopic dermatitis. Methods 35 patients with atopic dermatitis were selected as treatment group and 32 healthy workers as normal control group. The patients in the treatment group were treated with BCG polysaccharide nucleic acid for half a year, and Arrog was desensitized for 1 year. The serum total IgE,IL-2 and IL-4 levels were measured by radioimmunoassay in the control group and before and after treatment. Results the levels of serum IL-4 and IgE in patients with atopic dermatitis before treatment were (5.11 卤1.47) 渭 g 鈮，

本文编号：2502429