皮肤黑素瘤的分子检测和靶向治疗
发布时间：2019-07-17 07:43
【摘要】：黑素瘤的诊断和治疗是重要的临床课题。黑素瘤的组织学形态变异很多,与某些色素细胞痣之间存在中间型的组织形态学交叉,有时病理诊断相当困难。分子病理学的进展为皮肤黑素瘤的确诊提供了新的方法,同时也为黑素瘤的临床治疗提供了有价值的依据。BRAF,KIT,NRAS,HRAS等基因参与黑素瘤的发生和进展的MAPK通路和Akt/PI3K通路。DNA测序、外显子组测序、FISH技术、免疫组织化学技术可以检测黑素瘤相关的分子变化。针对黑素瘤发生分子通路的靶向治疗将使患者受益。
[Abstract]:The diagnosis and treatment of melanoma is an important clinical topic. There are many histomorphological variants in melanoma, and there are intermediate histomorphology intersecting with some pigmented nevi, which is sometimes difficult to diagnose pathologically. The progress of molecular pathology not only provides a new method for the diagnosis of skin melanoma, but also provides a valuable basis for the clinical treatment of melanoma. BRAF, KIT,NRAS,HRAS and other genes are involved in the occurrence and progress of melanoma MAPK pathway and Akt/PI3K pathway. DNA sequencing, exocrine group sequencing, FISH technology, immunohistochemistry can detect the molecular changes related to melanoma. Targeted therapy for the molecular pathway of melanoma will benefit patients.
【作者单位】： 胜利油田中心医院皮肤科;胜利油田中心医院病理科;
【分类号】：R739.5
[Abstract]:The diagnosis and treatment of melanoma is an important clinical topic. There are many histomorphological variants in melanoma, and there are intermediate histomorphology intersecting with some pigmented nevi, which is sometimes difficult to diagnose pathologically. The progress of molecular pathology not only provides a new method for the diagnosis of skin melanoma, but also provides a valuable basis for the clinical treatment of melanoma. BRAF, KIT,NRAS,HRAS and other genes are involved in the occurrence and progress of melanoma MAPK pathway and Akt/PI3K pathway. DNA sequencing, exocrine group sequencing, FISH technology, immunohistochemistry can detect the molecular changes related to melanoma. Targeted therapy for the molecular pathway of melanoma will benefit patients.
【作者单位】： 胜利油田中心医院皮肤科;胜利油田中心医院病理科;
【分类号】：R739.5
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