骨桥蛋白在寻常型银屑病中的表达及临床意义

发布时间：2019-07-18 11:16

【摘要】：目的检测骨桥蛋白(osteopontin,OPN)在寻常型银屑病皮损及血清中的表达,探讨OPN与银屑病危险因素的相关性。方法 1用免疫组化法检测15例寻常型银屑病患者皮损和10例正常人皮肤中的OPN的表达情况;2用酶联免疫吸附法(ELISA)检测55例寻常型银屑病患者和40例正常人血清中OPN的表达;3收集两组研究对象的临床资料,统计分析其与OPN表达的相关性。结果银屑病组皮损及血清OPN的表达均高于对照组(P0.05),银屑病组血清OPN表达与银屑病皮损面积和严重度指数(psoriasis area and severity index,PASI)评分呈正相关(P0.05),银屑病BMI超重组血清OPN的表达高于BMI正常组(P0.05)。结论 OPN可能参与了寻常型银屑病的发病过程,一定程度上能反映银屑病的严重程度。肥胖可能是银屑病患者OPN高表达的影响因素之一。
[Abstract]:Objective to detect the expression of osteopontin (osteopontin,OPN) in serum of psoriatic vulgaris and to explore the correlation between OPN and risk factors of psoriasis. Methods 1 Immunohistochemical method was used to detect the expression of OPN in the skin of 15 patients with psoriasis vulgaris and 10 normal subjects, (2) the expression of OPN in serum of 55 patients with psoriasis vulgaris and 40 normal subjects was detected by enzyme-linked immunosorbent assay (Elisa), and (3) the clinical data of the two groups were collected and the correlation between the expression of OPN and the expression of OPN was statistically analyzed. Results the expression of serum OPN in psoriatic group was higher than that in control group (P 0.05). The expression of serum OPN in psoriatic group was positively correlated with the score of psoriatic skin lesion area and severity index (psoriasis area and severity index,PASI (P 0.05). The expression of serum OPN in psoriatic BMI superrecombinant group was higher than that in normal BMI group (P 0.05). Conclusion OPN may be involved in the pathogenesis of psoriasis vulgaris and can reflect the severity of psoriasis to a certain extent. Obesity may be one of the factors affecting the high expression of OPN in patients with psoriasis.
【作者单位】：湖北省随州市中心医院皮肤科;华中科技大学同济医学院附属协和医院皮肤科;苏州儿童医院皮肤科;
【基金】：随州市卫计委科研资助项目(No.2012SMR015)
【分类号】：R758.63

【共引文献】