5%果酸治疗轻、中度痤疮58例临床观察

发布时间：2019-08-03 14:12

【摘要】：目的观察5%果酸治疗轻、中度痤疮和减轻痤疮后色素沉着的临床疗效。方法随机将入选的120例轻、中度痤疮患者分为两组,各60例。治疗组:用新鲜配制的5%果酸外搽面部皮损5~10min,冷喷15min,3次/周;对照组:每晚用药前清洗面部并擦干,再将异维A红霉素凝胶外搽患处,并轻轻按摩。两组患者的疗程均为12周,每3周1次观察并记录两组痤疮患者的疗效,治疗结束后观察两组患者的色素沉着发生情况。用药时避开眼周及口周皮肤,治疗期间停用其他化妆品及其他治疗痤疮的药物,嘱患者注意防晒,每日外搽防晒霜。结果治疗组有2例、对照组有4例因不良事件而中止或退出治疗,有效病例114例,治疗组58例,对照组56例。在治疗第3,6,9和12周时治疗组的有效率分别为20.69%,36.21%,65.52%和75.86%,对照组依次分别为12.50%,17.86%,42.85%和53.57%,且治疗第12周后治疗组色素沉着有效率(51.72%)明显高于对照组(26.79%);以上差异均有统计学意义(P均0.05)。两组患者出现的轻微不良反应经对症处理后均可消失。结论 5%果酸治疗轻、中度痤疮高效、安全而方便。
[Abstract]:Objective to observe the clinical effect of 5% fruit acid in the treatment of mild to moderate acne and the reduction of pigmentation after acne. Methods 120 patients with mild to moderate acne were randomly divided into two groups, 60 patients in each group. The treatment group was treated with fresh 5% fruit acid for 5 min 10 min, cold spray for 15 min, 3 times a week, while the control group: wash the face and dry it every night, then apply isovitamin A erythromycin gel to the affected area and massage gently. The course of treatment of both groups was 12 weeks. The curative effect of acne patients in both groups was observed and recorded every 3 weeks, and the occurrence of pigmentation in both groups was observed after treatment. Avoid the skin around the eye and mouth during treatment, stop using other cosmetics and other acne drugs during treatment, tell patients to pay attention to sunscreen and apply sunscreen daily. Results there were 2 cases in the treatment group, 4 cases in the control group were suspended or withdrawn because of adverse events, 114 cases were effective, 58 cases in the treatment group and 56 cases in the control group. At the 3rd, 6th, 9th and 12th week of treatment, the effective rates were 20.69%, 36.21%, 65.52% and 75.86% in the treatment group, 12.50%, 17.86%, 42.85% and 53.57% in the control group, respectively, and the effective rate of pigmentation in the treatment group (51.72%) was significantly higher than that in the control group (26.79%) after 12 weeks of treatment (P 0.05). The mild adverse reactions in both groups disappeared after symptomatic treatment. Conclusion 5% fruit acid is effective, safe and convenient in the treatment of mild to moderate acne.
【作者单位】：新疆维吾尔自治区人民医院皮肤性病科;
【分类号】：R758.733

【参考文献】