NB-UVB联合退白汤治疗寻常型白癜风的疗效及对Th17相关因子的调节作用

发布时间：2019-08-09 16:17

【摘要】：目的探讨退白汤联合窄谱中波紫外线(NB-UVB)治疗寻常型白癜风的疗效及对外周血IL-17,IL-22,IL-23的调节作用与临床意义。方法 138例寻常型白癜风患者分为治疗组、对照Ⅰ组、对照Ⅱ组各46例,每组又分为进展期和稳定期各23例。治疗组内服退白汤,2次/d,并予NB-UVB局部照射,2次/周;对照Ⅰ组单纯内服退白汤;对照Ⅱ组单纯使用NB-UVB局部照射,方法均同治疗组,3组疗程均为12周。另选志愿者30例作为健康对照组。分别于治疗前和治疗后检测健康对照组以及白癜风患者IL-17,IL-22,IL-23含量,同时评价临床疗效。结果治疗组进展期和稳定期有效率分别为91.30%和65.22%,对照Ⅰ组分别为65.22%和34.78%,对照Ⅱ组分别为60.87%和30.43%,治疗组与对照Ⅰ组、对照Ⅱ组进展期和稳定期分别比较,差异均有统计学意义(P0.05);治疗组进展期和稳定期、对照Ⅰ组和对照Ⅱ组进展期IL-17,IL-22,IL-23分别与治疗前比较,差异均有统计学意义(P0.05 or P0.01);治疗组与对照Ⅰ组、对照Ⅱ组比较,进展期和稳定期中上述各项指标差异均有统计学意义(P0.05)。结论退白汤联合NB-UVB治疗寻常型白癜风疗效显著,可能是通过降低患者血清中Th17细胞相关因子IL-17,IL-22,IL-23的含量来发挥治疗白癜风的作用。
[Abstract]:Objective to investigate the efficacy of Huibai decoction combined with narrow band ultraviolet (NB-UVB) in the treatment of vitiligo vulgaris and the regulatory effect and clinical significance of IL-17,IL-22,IL-23 in peripheral blood. Methods 138 patients with vitiligo vulgaris were divided into treatment group (n = 46) and control group (n = 46). Each group was divided into progressive stage (n = 23) and stable stage (n = 23). The treatment group was treated with Tuibai decoction twice a day, and NB-UVB was irradiated locally twice a week, while the control group 鈪，

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