西宁地区急性缺血性脑卒中氧化低密度脂蛋白与神经功能缺损程度的相关性研究

发布时间：2017-12-26 18:24

本文关键词：西宁地区急性缺血性脑卒中氧化低密度脂蛋白与神经功能缺损程度的相关性研究　出处：《青海大学》2016年硕士论文　论文类型：学位论文

【摘要】：目的:本实验研究西宁地区急性缺血性脑卒中患者血浆氧化低密度脂蛋白(Oxidized low density lipoprotein OXLDL)与神经功能缺损程度的关系,为急性缺血性脑卒中患者的病情判断、估计预后、危险预测提供依据。方法:收集并整理2013年3月至2014年3月青海省人民医院神经内科收住入院的汉族急性脑梗死病人120例。按照美国国立卫生院制定的神经功能缺损评分(NIHSS评分)对患者进行神经缺损评估,根据神经功能缺损程度评分分为3组:≤4分为轻度,4分且≤25分为中度,25分为重度,其中轻度58例,年龄(62.21±9.75)岁;中度43例,年龄(63.41±11.94)岁;重度19例,年龄(60.68±11.59)岁。血浆OXLDL水平采用ELISA法检测。采用单因素方差分析方法及pearson相关分析对各组间比较,研究OXLDL与神经功能缺损程度的相关性。根据MRI梗死面积大小按照admas分类法分为三组,采用单因素方差分析方法及pearson相关分析对各组间比较,研究OXLDL与梗死面积的相关性。结果:1.轻度神经功能缺损、中度神经功能缺损与重度神经功能缺损患者各组间一般资料比较,无统计学意义(P0.05);2.轻、中、重度神经功能缺损组间OXLDL水平比较有明显差异,有统计学意义(P0.05);3.相关性分析示:神经功能缺损评分与OXLDL水平相关性分析呈正相关性(R=0.474,P0.05);4.不同脑梗死面积患者之间的氧化低密度脂蛋白水平比较,差异有统计学意义(P0.05);5.相关性分析示:脑梗死面积与OXLDL水平呈正相关性(R=0.647,P0.05)。结论:西宁地区急性缺血性脑卒中患者氧化低密度脂蛋白含量变化与神经功能缺损程度存在正相关,并且与脑梗死面积存在正相关,揭示OXLDL为脑梗死危险因素之一,在评估急性脑梗塞的病情及预后方面有一定的临床意义。
[Abstract]:Objective: This study of Xining area in patients with acute ischemic stroke of oxidized low density lipoprotein (Oxidized low density lipoprotein OXLDL) and the relationship between the degree of neurological impairment, judgment, for patients with acute ischemic stroke disease provides evidence for the estimation of prognosis and risk prediction. Methods: 120 patients with acute cerebral infarction were collected and collected from March 2013 to March 2014 in the Department of Neurology of Qinghai People's Hospital. According to the score of nerve function defect formulated by the National Institutes of Health (NIHSS score) for nerve defect assessment for patients, according to the degree of neurological deficit score were divided into 3 groups: less than or equal to 4 divided into mild, 4 and less than 25 for moderate, 25 as severe, including 58 mild cases, age (62.21 + 9.75) at the age of 43; moderate cases, age (63.41 + 11.94) years; 19 severe cases, age (60.68 + 11.59) years old. The level of plasma OXLDL was detected by ELISA. The correlation between OXLDL and the degree of nerve function defect was studied by single factor analysis of variance and Pearson correlation analysis. According to the size of MRI infarct size, the rats were divided into three groups according to ADMAS classification. The correlation between OXLDL and infarct size was compared between the groups by one-way ANOVA and Pearson correlation analysis. Results: 1. mild neurological deficit, moderate neurological deficit and severe neurological deficits in patients with inter group comparison of general information, no statistical significance (P0.05); 2. light, moderate and severe neurological impairment group OXLDL level had significant difference compared with statistical significance (P0.05, 3.); correlation analysis showed: the correlation of neural function defect score and OXLDL level analysis showed positive correlation (R=0.474, P0.05); comparison between the 4. different area of cerebral infarction in patients with oxidized low density lipoprotein level, the difference was statistically significant (P0.05); 5. correlation analysis showed: the cerebral infarction area was correlated with OXLDL levels (R=0.647, P0.05). Conclusion: there is a positive correlation in Xining area changes in patients with acute ischemic stroke oxidized low density lipoprotein content and the degree of neurological deficit, and there is a positive correlation with the area of cerebral infarction, revealed OXLDL as one of the risk factors of cerebral infarction, has certain clinical significance in acute cerebral infarction and prognosis of the disease.
【学位授予单位】：青海大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R743.3

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