脑梗死超急性期静脉溶栓治疗的效果

发布时间：2017-12-27 08:54

本文关键词：脑梗死超急性期静脉溶栓治疗的效果　出处：《中华卫生应急电子杂志》2016年03期 　论文类型：期刊论文

【摘要】：目的探讨静脉溶栓疗法应用于急性脑梗死(ACI)患者中的临床疗效。方法随机选择2012年6月至2016年3月东莞市中医院神经内科病房收治的ACI患者60例,其中男性37例,女性23例,平均年龄(68.2±8.5)岁。按照随机数字表法分为对照组和观察组。对照组(30例)给予常规内科治疗,观察组(30例)则在对照组基础上给予重组组织型纤溶酶原激活物(rt-PA)静脉溶栓治疗。并比较两组的美国国立卫生研究院卒中量表(NIHSS)评分以及实验室指标以评价临床效果。结果观察组患者从治疗后第1,3,5,7,14 d的NIHSS评分均显著低于对照组,通过双因素方差分析,两组差异具有统计性(P0.05)。治疗前后,观察组(30例)27例有效,总有效率为90%,明显高于对照组(30例)9例有效,有效率为30%,同时经轶和检验两组具有统计学差异(χ~2=22.50,P0.05)。观察组中,半身不遂及舌强语蹇减分值明显高于对照组,差异具有统计学意义(P0.05),观察组血管紧张素I为36.64±14.63 mmol/L,显著高于对照组的25.71±16.99 mmol/L,而白介素-6为68.75±46.46 mmol/L,明显地低于对照组的89.91±37.42 mmol/L(P0.05),其他理化指标在两组间差异无统计学意义(P0.05)。经轶和检验,观察组在风证、痰证和疲证方面的疗效优于对照组(P0.05),而其他四类证候差异无统计学意义(P0.05)。结论本研究结果表明静脉溶栓疗法能够有效治疗急性脑梗死,改善患者生存质量,值得临床推广。
[Abstract]:Objective to investigate the clinical efficacy of intravenous thrombolytic therapy in patients with acute cerebral infarction (ACI). Methods a total of 60 patients with ACI were selected from June 2012 to March 2016 in the neurology ward of Dongguan Hospital of traditional Chinese medicine, including 37 males and 23 females, with an average age of (68.2 + 8.5) years. According to the random number table method, the control group and the observation group were divided into the control group and the observation group. The control group (30 cases) was given conventional medical treatment, while the observation group (30 cases) was given thrombolytic therapy with recombinant tissue plasminogen activator (rt-PA) on the basis of the control group. The two groups of the National Institutes of Health Stroke Scale (NIHSS) score and laboratory indicators were compared to evaluate the clinical effects. Results the NIHSS scores of the observation group were significantly lower than those of the control group after treatment. The difference between the two groups was statistically significant (P0.05) by two factor analysis of variance (1,3,5,7,14). The difference between the two groups was statistically significant (P0.05). Before and after treatment, the observation group (30 cases) and 27 cases were effective, the total effective rate was 90%, significantly higher than the control group (30 cases) and 9 cases were effective, effective rate was 30%, while the two Yi and test group with significant difference (~2=22.50, P0.05). In the observation group, hemiplegia and stiff tongue Jian minus score significantly higher than the control group, the difference was statistically significant (P0.05), the observation group of angiotensin I was 36.64 + 14.63 mmol/L, significantly higher than the control group of 25.71 + 16.99 mmol/L, and IL -6 68.75 + 46.46 mmol/L, significantly lower than the control group 89.91 + 37.42 mmol/L (P0.05), no statistically significant differences in other physicochemical indexes between the two groups (P0.05). By Yi and inspection, curative effect observation group in the wind syndrome and phlegm syndrome and fatigue syndrome is better than that of control group (P0.05), but no significant differences in the other four types of syndromes (P0.05). Conclusion the results of this study show that intravenous thrombolytic therapy can effectively treat acute cerebral infarction and improve the quality of life of the patients. It is worthy of clinical application.
【作者单位】：东莞市中医院内三科;南方医科大学珠江医院急诊科;
【分类号】：R743.3
【正文快照】： 脑梗死也称为缺血性脑卒中(cerebral ischemicstroke,CIS),是临床常见的脑血管疾病,具有较高的致死、致残率[1]。脑梗死是指因脑组织局部血液供应障碍,脑组织对缺血缺氧高度敏感,脑组织发生缺血、缺氧现象,脑动脉急性闭塞导致缺血性脑梗死,肢体活动障碍、身体感觉障碍等[2-4]

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