帕金森叠加综合征的临床与影像学特点分析

发布时间：2017-12-28 00:26

本文关键词：帕金森叠加综合征的临床与影像学特点分析　出处：《现代医学》2016年11期 　论文类型：期刊论文

【摘要】：目的:探讨帕金森叠加综合征(PPS)的临床及影像学特点。方法:选取我院治疗的PPS患者45例,包括多系统萎缩(MSA)患者38例[其中以帕金森症状为主型(MSA-P)18例,小脑症状为主型(MSA-C)20例]、进行性核上性麻痹(PSP)患者7例;同时选取帕金森病(PD)患者25例。观察各组临床症状及影像学资料。结果:PD组病程长于MSA-P、MSA-C和PSP组(P0.05),PD组Hoehn-Yahr评分明显低于MSA-P和PSP组(P0.05),各组患者震颤、强直等临床症状发生差异有统计学意义(P0.05),各组患者小脑上脚(SCP)宽度、小脑中脚(MCP)宽度等磁共振形态测量参数差异有统计学意义(P0.05)。结论:PPS不同临床亚型可有不同的临床特点,磁共振形态测量可为PPS的诊断提供依据。
[Abstract]:Objective: To investigate the clinical and imaging features of Parkinson superposition syndrome (PPS). Methods: 45 cases of PPS in our hospital were selected, including 38 patients with multiple system atrophy (MSA), including 18 cases of Parkinson's symptom (MSA-P), 20 cases of cerebellar symptoms (MSA-C), 7 cases of progressive supranuclear paralysis (PSP), and 25 cases of Parkinson disease (PD) at the same time. The clinical symptoms and imaging data of each group were observed. Results: PD group was longer than that of MSA-P, MSA-C and PSP group (P0.05), PD group, Hoehn-Yahr score was significantly lower than that in MSA-P and PSP group (P0.05), groups of patients with clinical symptoms such as tremor and rigidity difference had statistical significance (P0.05), each group of superior cerebellar peduncle (SCP) width and small feet in the brain (MCP) there were statistically significant differences in measured parameters such as width of magnetic resonance form (P0.05). Conclusion: different clinical subtypes of PPS can have different clinical characteristics. Magnetic resonance morphometry can provide a basis for the diagnosis of PPS.
【作者单位】：四川省达州市中心医院神经内科;
【分类号】：R742.5
【正文快照】： 帕金森叠加综合征(Parkinsonism-plus syndrome,PPS)患者疾病谱主要包括进行性核上性麻痹、多系统萎缩(MSA)和基底节变性等:u。PPS和特发性帕金森病(Parkinson’s disease,PD)的病理生理基础均为神经元变性所引起的运动障碍21,并可致锥体外神经系统病变。该病早期临床症状特异

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