依达拉奉注射液联合丁苯酞治疗急性脑梗死的疗效观察

发布时间：2017-12-28 07:18

本文关键词：依达拉奉注射液联合丁苯酞治疗急性脑梗死的疗效观察　出处：《药物评价研究》2016年04期 　论文类型：期刊论文

【摘要】：目的观察依达拉奉联合丁苯酞治疗急性脑梗死的临床疗效。方法选取200例在宝鸡市人民医院就诊的急性脑梗死患者,随机分为观察组100例,给予依达拉奉注射液联合丁苯酞治疗,对照组100例,仅给予丁苯酞治疗。对两组患者的临床疗效、NDS评分、Mo CA评分、ADL评分及血清C-反应蛋白(hs-CRP)水平及不良反应进行比较。结果观察组总有效率(92%)显著高于对照组(79%),差异具有统计学意义(P0.05)。治疗后两组患者神经功能缺损均有所下降,认知功能均有所改善,但观察组神经功能缺损下降显著低于对照组,认知功能改善优于对照组,观察组ADL评分显著高于对照组,hs-CRP水平显著低于对照组,差异具有统计学意义(P0.05)。所有患者治疗过程中无明显不良反应。结论依达拉奉注射液联合丁苯酞对急性脑梗死疗效显著,安全性好,值得临床推广。
[Abstract]:Objective To observe the clinical efficacy of edaravone combined with butylphthalide in the treatment of acute cerebral infarction. Methods 200 patients with acute cerebral infarction who were treated in Shaanxi Baoji People's Hospital were randomly divided into observation group and control group, 100 cases were given Edaravone Injection combined with butylphthalide, while 100 cases in control group were treated with butylphthalide. The clinical efficacy, NDS score, Mo CA score, ADL score and serum C- reactive protein (hs-CRP) level and adverse reaction were compared in two groups of patients. Results the total effective rate of the observation group (92%) was significantly higher than that of the control group (79%), and the difference was statistically significant (P0.05). After treatment, two groups of patients with neurological deficits were decreased, the cognitive function were improved, but the observation group decreased neurological deficit was significantly lower than the control group, the cognitive function was better than the control group, ADL score in observation group was significantly higher than the control group, the level of hs-CRP was significantly lower than the control group, the difference was statistically significant (P0.05). There was no obvious adverse reaction during the treatment of all patients. Conclusion the combination of Edaravone Injection and butylphthalide has a significant effect on acute cerebral infarction, and it is safe and worthy of clinical application.
【作者单位】：宝鸡市人民医院干部病区;华阴市人民医院神经内科;
【分类号】：R743.3
【正文快照】： 急性脑梗死是神经内科的常见病,常伴有不同程度的认知功能障碍,有很高的发病率和致残率。患者坏死区的神经细胞迅速死亡,而局部微循环障碍和自由基损伤是引起神经细胞凋亡的主要原因[1-2]。丁苯酞通过抗脑缺血和改善缺血区微循环等恢复神经功能和改善认知功能[3]。依达拉奉是

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