孕期新型抗癫痫药物的合理应用和研究进展

发布时间：2018-01-02 22:23

本文关键词：孕期新型抗癫痫药物的合理应用和研究进展　出处：《中华妇幼临床医学杂志(电子版)》2016年01期 　论文类型：期刊论文

【摘要】：癫痫是神经系统的一种常见慢性疾病,约25%癫痫患者为育龄期妇女,而该类患者为控制痫性发作,即使在孕期也必须坚持口服抗癫痫药物(AED)治疗。AED可不同程度地通过胎盘屏障进入胎儿体内,对其健康产生潜在危害。新型AED由于具有相对较低的致畸风险,而倍受临床医师和癫痫患者的青睐。但妊娠所致的新型AED药代动力学改变,却对该药在癫痫患者孕期中的应用带来巨大挑战。因此,孕期应对癫痫患者进行系统的健康教育和用药指导、规律的血药浓度监测、严格的产前检查及恰当的叶酸制剂补充,以达到新型AED在癫痫患者孕期的个体化治疗。
[Abstract]:Epilepsy is a common chronic disease of the nervous system, about 25% of patients with epilepsy in women of childbearing age, and the patients to control seizures, even during pregnancy must also adhere to the oral antiepileptic drugs (AED) treatment of.AED degree through the placental barrier to the fetus, the health of the potential harm model. Because AED is teratogenic risk is relatively low, by clinicians and patients with epilepsy caused by pregnancy. But in favor of the new AED pharmacokinetic change, has brought enormous challenges to the application of the drug in patients with epilepsy during pregnancy. Therefore, health education and medication guide to patients with epilepsy during pregnancy system, blood drug concentration monitoring the law, strict and supplementary prenatal folic acid supplements appropriate, in order to achieve the new AED in the individualized treatment of pregnancy in patients with epilepsy.

【作者单位】：四川大学华西第二医院妇产科;四川大学华西医院神经内科;
【基金】：四川省科技计划项目(2014JY0214)~~
【分类号】：R742.1
【正文快照】： 癫痫是大脑神经元突然异常放电所致短暂性中枢神经系统功能失调的一种慢性综合征,是神经系统第二大常见疾病,已被世界卫生组织(World Health Organization,WHO)列为五大重点防治的神经精神疾病之一。据统计,约25%癫痫患者为育龄期妇女[1],每年约有0.3%~0.4%新生儿由患有癫痫的

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