高压氧对急性脑出血患者NSE、BDNF及sICAM-1的影响及与脑水肿相关性研究

发布时间：2018-01-07 09:06

本文关键词：高压氧对急性脑出血患者NSE、BDNF及sICAM-1的影响及与脑水肿相关性研究　出处：《湖南师范大学学报(医学版)》2016年06期 　论文类型：期刊论文

【摘要】：目的 :探讨高压氧对急性脑出血患者神经元特异性烯醇化酶(NSE)、脑源性神经营养因子(BDNF)及细胞间粘附分子-1(sICAM-1)的影响及与脑水肿相关性。方法 :分析2015年1月~2016年6月103例在我院接受治疗的急性脑出血的患者的临床资料,对照组(54例)给予脱水降颅压、营养脑组织,改善脑循环代谢功能,维持酸碱平衡等对症支持治疗。观察组(49例)在对照组的基础上入院3天内给予高压氧治疗。结果 :两组患者接受不同的治疗方案后,观察组患者血清NSE、s ICAM-1水平明显低于对照组,观察组血清BDNF水平明显高于对照组,差异均具有统计学意义;治疗后观察组患者相对脑水肿体积及NIHSS评分水平明显低于对照组;治疗后观察组患者血清NSE及sICAM-1水平与相对脑水肿体积呈正相关,而血清BDNF与相对脑水肿体积呈负相关。结论 :高压氧可明显改善急性脑出血患者脑水肿症状,促进缺损神经功能的恢复,血清NSE、BDNF及sICAM-1的改变可能与脑水肿发病机制存在一定的相关性。
[Abstract]:Objective: To investigate the effects of hyperbaric oxygen in patients with neuron specific enolase in patients with acute cerebral hemorrhage (NSE), brain-derived neurotrophic factor (BDNF) and intercellular adhesion molecule -1 (sICAM-1) and the effect of correlation with brain edema. Methods: to analyze the clinical data of January 2015 ~2016 year in June 103 cases of patients with acute brain treated in our Institute of hemorrhage, the control group (54 cases) treated with dehydration to reduce intracranial pressure, brain nutrition, improve cerebral circulation and metabolism, maintaining acid-base balance and other symptomatic and supportive treatment. The observation group (49 cases) in the control group based on the admission of high pressure oxygen treatment given within 3 days. Results: the two groups of patients different treatment, serum NSE, s level of ICAM-1 was significantly lower than the control group, the serum level of BDNF group was significantly higher than the control group, the difference was statistically significant; after treatment, the patients in the observation group were relative cerebral edema volume and NIHSS score level Ming Significantly lower than the control group; the observation group of patients with positive serum NSE and sICAM-1 levels and the relative volume of brain edema after treatment, serum BDNF and cerebral edema volume was negatively correlated. Conclusion: hyperbaric oxygen therapy can significantly improve symptoms in patients with acute cerebral hemorrhage and edema, promote the recovery of neural function defect, serum NSE, BDNF and sICAM-1 change and pathogenesis of brain edema may have certain correlation.

【作者单位】：延安大学附属医院;
【分类号】：R743.34
【正文快照】： 急性脑出血(Acute cerebral hemorrhage)是突发非脑外伤性脑实质内血管破裂引起的一种出血性疾病,起病较为急骤,临床上因出血部位及出血量不同,常引起患者不同程度的运动、认知及言语吞咽障碍,致残率和致死率较高[1,2],占全部脑卒中的30%左右[3]。高压氧(Hyperbaric oxygen,HB

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