丙戊酸钠联合左乙拉西坦治疗小儿癫痫的疗效及安全性

发布时间：2018-01-08 13:22

  本文关键词：丙戊酸钠联合左乙拉西坦治疗小儿癫痫的疗效及安全性　出处：《中国医院用药评价与分析》2016年07期 　论文类型：期刊论文

  更多相关文章： 癫痫 丙戊酸钠 左乙拉西坦 托吡酯

【摘要】：目的:探讨丙戊酸钠联合左乙拉西坦小儿癫痫的疗效及安全性。方法:选取2014年2月—2015年2月收治的82例癫痫患儿,按随机数字表法分为对照组41例和观察组41例。对照组患儿给予丙戊酸钠联合托吡酯,观察组患儿给予丙戊酸钠联合左乙拉西坦,观察2组患儿的疗效、相关实验室指标及不良反应发生情况。结果:治疗后,观察组患儿的总有效率为95.12%(39/41),明显高于对照组的80.49%(33/41),差异有统计学意义(P0.05);2组患儿血钙、血磷水平均较治疗前降低,且观察组改善情况优于对照组,差异有统计学意义(P0.05);2组患儿均未见严重不良反应发生。结论:丙戊酸钠联合左乙拉西坦治疗小儿癫痫的疗效显著,可明显改善患儿症状,安全性较高,在临床中具有良好的应用价值。
[Abstract]:Objective: To investigate the efficacy and safety of combination of sodium valproate and levetiracetam in children with epilepsy. Methods: 82 cases of children with epilepsy from February 2014 to February 2015 were selected and randomly divided into control group of 41 cases and 41 cases in the observation group. The control group was treated with valproate and topiramate, observation group were given sodium valproate combined with left etiracetam, to observe the curative effect of 2 groups of children, the incidence of related laboratory parameters and adverse reactions. Results: after the treatment, the observation group with the total effective rate was 95.12% (39/41), significantly higher than the control group 80.49% (33/41), the difference was statistically significant (P0.05); 2 groups of children with lower blood calcium, phosphorus levels were compared with before treatment, and the observation group improved better than the control group, the difference was statistically significant (P0.05); the 2 groups had no serious adverse reactions. Conclusion: sodium valproate combined with left B Lacita treatment of pediatric epilepsy therapy It has remarkable effect and can obviously improve the symptoms and safety of the children. It has good application value in clinic.

【作者单位】： 佛山市顺德区伍仲s罴湍钜皆阂┬悼，

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