氯吡格雷联合阿司匹林治疗急性大动脉粥样硬化型卒中患者预防早期神经功能恶化及改善结局效果评价

发布时间：2018-01-12 16:07

本文关键词：氯吡格雷联合阿司匹林治疗急性大动脉粥样硬化型卒中患者预防早期神经功能恶化及改善结局效果评价　出处：《中风与神经疾病杂志》2016年11期 　论文类型：期刊论文

【摘要】：目的评估阿司匹林联合氯吡格雷治疗对于急性大动脉粥样硬化型卒中患者早期神经功能恶化和6m结局的影响。方法 574例大动脉粥样硬化型卒中患者被随机分配到联合治疗组或阿司匹林单药治疗组。主要结局指标是早期神经功能恶化。次要结局指标是复发缺血性卒中和6m结局。结果联合治疗组30d时的神经功能恶化率和卒中复发率低于单药治疗组。联合治疗能够改善老年患者,症状性后循环和基底动脉狭窄患者6m随访结局。结论阿司匹林和氯吡格雷联合治疗在减少30d时神经功能恶化率和缺血性卒中复发率方面优于阿司匹林单药治疗,同时联合治疗也能改善特定亚组的6m结局。
[Abstract]:Objective to evaluate the effect of aspirin combined with clopidogrel on early neurological deterioration and 6 m outcome in patients with acute atherosclerotic stroke. 574 patients with atherosclerotic stroke were randomly assigned to the combined treatment group or aspirin group. The main outcome indicators were early neurological deterioration and secondary outcome indicators were recurrent ischemic stroke and 6. M outcome. The neurological function deterioration rate and stroke recurrence rate in the combined treatment group were lower than those in the single drug treatment group at 30 days, and the combination treatment could improve the elderly patients. Results of 6 m follow-up in patients with symptomatic posterior circulation and basilar artery stenosis. The combined therapy of aspirin and clopidogrel was superior to aspirin alone in reducing the rate of neurological deterioration and ischemic stroke recurrence at 30 days. At the same time, combined therapy can also improve the 6 m outcome of a specific subgroup.
【作者单位】：四川省德阳市人民医院神经内科;
【分类号】：R743
【正文快照】： 在世界范围内卒中已成为影响人类健康的重大问题,并且卒中患病率随人口年龄增长呈上升趋势。短暂性脑缺血发作或缺血性卒中发生后的早期阶段,尤其在卒中发生后数小时至数天时间内,就存在很高的卒中复发风险[1,2];同时,早期神经功能缺损恢复良好的患者也存在较高的神经功能恶化

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