脑脊液肝素结合蛋白和降钙素原在细菌性颅内感染诊断中的应用

发布时间：2018-01-13 08:13

本文关键词：脑脊液肝素结合蛋白和降钙素原在细菌性颅内感染诊断中的应用　出处：《临床检验杂志》2016年04期 　论文类型：期刊论文

【摘要】：目的探讨脑脊液中肝素结合蛋白(HBP)和降钙素原(PCT)在细菌性颅内感染诊断中的应用价值。方法收集2015年3月至8月在湘雅二医院住院的颅内感染患者64例,分为细菌性感染组(23例)、病毒性感染组(16例)、结核性感染组(14例)、隐球菌性感染组(11例),同时选择33例脑脊液白细胞计数(WBC)10×106/L的非颅内感染性疾病患者作为对照组。测定并统计分析患者脑脊液中WBC、总蛋白(TP)、葡萄糖(Glu)、HBP和PCT水平。结果细菌性感染组脑脊液HBP均高于病毒性感染组、隐球菌性感染组和对照组(P均0.05),PCT均高于病毒性感染组、结核性感染组和对照组(P均0.05)。脑脊液HBP、WBC、TP和PCT水平诊断细菌性颅内感染的ROC曲线下面积分别为0.909、0.694、0.703、0.711;当cut-off值分别为24.2 ng/m L、82.0×106/L、788.6 mg/L、0.125 ng/m L时,敏感性分别为73.9%、73.9%、65.2%、43.5%,特异性分别为87.8%、58.5%、70.7%、90.2%。结论脑脊液HBP是一种有价值的诊断细菌性颅内感染的指标,在鉴别细菌性颅内感染与病毒性颅内感染时价值更高;而脑脊液PCT诊断细菌性颅内感染的价值与脑脊液WBC等传统指标相比优势不明显。
[Abstract]:Objective to investigate the levels of heparin binding protein (HBP) and procalcitonin (PCT) in cerebrospinal fluid (CSF). Methods from March 2015 to August, 64 patients with intracranial infection in Xiangya Hospital were collected. It was divided into bacterial infection group (n = 23), viral infection group (n = 16), tuberculous infection group (n = 14) and cryptococcal infection group (n = 11). At the same time, 33 patients with WBC10 脳 10 6 / L WBC 10 脳 10 6 / L were selected as control group. WBC (total protein TPV) in cerebrospinal fluid (CSF) was measured and analyzed statistically. Results the levels of HBP in cerebrospinal fluid of bacterial infection group were higher than that of viral infection group, and that of Cryptococcus infection group and control group were 0.05). The levels of PCT were higher than that of viral infection group, the tuberculous infection group and the control group were both 0.05. The area under the ROC curve of TP and PCT for the diagnosis of bacterial intracranial infection was 0.909 / 0.694 / 0.703 / 0. 711, respectively. When the cut-off value is 24.2 ng/m / L ~ (82) 脳 10 ~ (-6) / L ~ (78. 6) mg / L ~ (0.125) ng/m / L, respectively. The sensitivities were 73.9% and 65.2%, and the specificity was 87.8% and 58.5%, respectively. Conclusion Cerebrospinal fluid (CSF) HBP is a valuable index for the diagnosis of bacterial intracranial infection, which is more valuable in differentiating bacterial intracranial infection from viral intracranial infection. The value of cerebrospinal fluid (PCT) in the diagnosis of bacterial intracranial infection was not significantly superior to that of cerebrospinal fluid (CSF) WBC.
【作者单位】：中南大学湘雅二医院检验科;湖南师范大学医学院;
【基金】：湖南省科学技术厅科技计划(2014FJ3096)
【分类号】：R51;R529.3;R446.14
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