自噬与小胶质细胞相关神经炎症

发布时间：2018-01-13 14:09

本文关键词：自噬与小胶质细胞相关神经炎症　出处：《中国生物化学与分子生物学报》2016年09期 　论文类型：期刊论文

【摘要】：小胶质细胞是中枢神经系统中重要的神经免疫细胞,当中枢神经系统受到刺激后,小胶质细胞通过炎症反应来应对这种刺激,这种炎症反应在神经性疾病中具有重要作用。研究发现,小胶质细胞自噬在炎症的发生与发展中也发挥了重要作用,它能直接或间接地影响炎症反应,同时自身也被其他信号调控。自噬过程有利有弊,适当的自噬过程能促进疾病的恢复,自噬紊乱则使病情恶化,所以明确自噬的调控机制对治疗和预防相关疾病具有重要意义。本文综述了近年来自噬在小胶质细胞相关炎症中研究进展,以及其可能的调控机制,以期为相关研究人员提供一定帮助。
[Abstract]:Microglia are important neural immune cells in central nervous system, when the central nervous system stimulation of microglia through inflammation to respond to this stimulus, the inflammatory reaction plays an important role in neurological diseases. The study found that autophagy of microglia in the occurrence and development of inflammation also played an important role in and it can directly or indirectly influence the inflammatory reaction, but also by other signal control. The process of autophagy autophagy appropriate There are both advantages and disadvantages., can promote the recovery of the disease, autophagy disorders make the condition worse, so the regulation mechanism of autophagy clearly has important significance for the prevention and treatment of related diseases. This paper reviews the research progress from the bite in microglia inflammation, and its possible mechanism, in order to provide some help for the related researchers.

【作者单位】：大连大学生命科学与技术学院辽宁省糖脂代谢研究重点实验室;
【基金】：国家自然科学基金项目(No.81373429,81070973,81671243) 大连金州新区科技计划项目(No.KJCX-ZTPY-2014-0014)资助~~
【分类号】：R741
【正文快照】： 81373429,81070973,81671243),Science and Technology PlanProjects of Dalian Jinzhou New District(No.KJCX-ZTPY-2014-0014)*Corresponding author Tel:0411-87402310;E-mail:wuhaige@dlu.edu.cn自噬是细胞内的分解代谢途径,通过自噬体把一些可溶性大分子或细胞器等运输到

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