无先兆偏头痛发作间期的静息态功能磁共振研究

发布时间：2018-01-16 08:15

本文关键词：无先兆偏头痛发作间期的静息态功能磁共振研究　出处：《脑与神经疾病杂志》2016年02期 　论文类型：期刊论文

【摘要】：目的本研究采用静息态功能磁共振(rf MRI)方法通过对比无先兆偏头痛(Mwo A)患者与健康对照的大脑自发脑活动的局部一致性(Re Ho)差异,为偏头痛的发病机制提供新的见解。方法对23例发作间期的Mwo A患者和25例性别、年龄、受教育程度相匹配的健康被试者进行临床资料的采集及rf MRI检查。应用Re Ho方法分析每个被试者大脑的相邻体素的血氧水平依赖(BOLD)信号在同一时间序列中波动的一致性,并对两组被试者的Re Ho值的脑图行统计学分析。结果与对照组Re Ho脑图相比,偏头痛组右侧丘脑、右侧壳核、右侧前额叶皮质及右侧海马的Re Ho值显著高于对照组(P0.05)。结论 Mwo A患者发作间期疼痛处理及调节与应激反应相关的脑区存在功能异常。
[Abstract]:Objective to compare the local consistency of brain spontaneous brain activity between patients without aura migraine and healthy controls using resting functional magnetic resonance imaging (Mr RF MRI) method. Difference. Methods 23 patients with interictal Mwo A and 25 patients with gender and age were studied. The clinical data and RF MRI of healthy subjects matched with education were collected. Re Ho method was used to analyze the blood oxygen level dependence of adjacent voxels in the brain of each of the subjects. The consistency of signal fluctuations in the same time series. Results compared with the control group, the right thalamus and right putamen nucleus of migraine group were compared with those of control group. Re Ho in the right prefrontal cortex and the right hippocampus was significantly higher than that in the control group (P 0.05). Conclusion in Mwo A patients, interictal pain management and regulation of stress response related brain regions are abnormal.
【作者单位】：邢台市人民医院神经内科;河北医科大学第二医院神经内科河北省神经病学重点实验室;河北医科大学第二医院影像科;
【基金】：河北省应用基础研究计划重点基础研究项目(13967711D)
【分类号】：R747.2
【正文快照】： 偏头痛是一种中-重度的、多为单侧的及搏动性的原发性头痛。偏头痛中最常见的亚型为无先兆偏头痛(migraine without aura,Mwo A),约占3/4。各国报道的年患病率,女性为3.3%~32.6%,男性为0.7%~16.1%[1]。偏头痛的神经影像学研究导致人们对偏头痛的病理机制观点由单血管假说转变

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