血清尿酸、颈动脉硬化与脑梗死严重程度的相关性探讨

发布时间：2018-01-19 04:07

本文关键词： 尿酸颈动脉粥样硬化脑梗死疾病严重程度　出处：《湖南师范大学学报(医学版)》2016年06期 　论文类型：期刊论文

【摘要】：目的 :探讨血清尿酸、颈动脉粥样硬化(CAS)与急性脑梗死(ACI)严重程度的相关性。方法 :收集ACI患者123例,根据神经缺损评分分为轻、中、重3组,分别为56、39、28例,另有40例健康体检者为健康组。所有对象来院时予即刻抽血检验血清尿酸(UA)水平,并行颈动脉超声检查,记录颈动脉内-中膜厚度(IMT)、斑块情况,并计算Crouse积分。结果 :中、重度组的血UA水平、斑块检出率、不稳定性斑块形成率较轻度组、健康组均显著升高。中度组的IMT、Crouse积分水平显著高于健康组,重度组的IMT、Crouse积分水平较健康、轻度、中度组均显著升高。ACI患者的血UA水平与IMT、Crouse积分水平呈正相关,稳定性、不稳定性斑块ACI患者UA水平较无斑块者显著升高,其中不稳定性斑块组UA水平较稳定性斑块组进一步升高。结论 :血尿酸升高促进颈动脉粥样硬化斑块的形成。尿酸水平越高,斑块性质可能越不稳定,脑梗死发生时程度可能更严重。
[Abstract]:Objective: to investigate the relationship between serum uric acid, carotid atherosclerosis (CAS) and severity of acute cerebral infarction (ACI). Methods: 123 patients with ACI were collected. According to the score of nerve defect, 28 cases were divided into 3 groups: mild, medium and heavy. In addition, 40 healthy persons were in the healthy group. All the subjects were examined for serum uric acid and UAA levels immediately when they came to hospital, and carotid artery ultrasound was performed to record IMT (carotid intima-media thickness). Results: the serum UA level, plaque detection rate and unstable plaque formation rate in moderate and severe group were significantly higher than those in mild group and healthy group. IMT in moderate group was significantly higher than that in moderate group. The level of Crouse score was significantly higher than that of healthy group, and the level of serum UA and IMT in severe group was significantly higher than that in healthy group, mild group and moderate group. The level of Crouse score was positively correlated, and the UA level in unstable plaque patients with ACI was significantly higher than that in patients without plaque. The UA level in the unstable plaque group was higher than that in the stable plaque group. Conclusion: the higher the uric acid level is, the more unstable the plaque may be. The degree of cerebral infarction may be more serious.
【作者单位】：衡水市第四人民医院神经内二科;
【基金】：项目基金:急性脑梗死与血尿酸关系的临床研究(NO.15078)
【分类号】：R743.33
【正文快照】： 目前,高尿酸血症/痛风、动脉粥样硬化、脑梗死均已成为我国中老年人常见的疾病。其中,高尿酸血症近年来被认为与动脉粥样硬化存在密切关系,有相关报道发现动脉粥样硬化斑块中的尿酸(uric acid,UA)结晶较正常动脉管壁增多,以及血清UA水平升高与颈动脉内膜增厚/粥样硬化直接相关

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