Cerebrolysin治疗吉兰—巴雷综合征的疗效观察

发布时间：2018-01-20 08:24

本文关键词： 吉兰—巴雷综合征 Cerebrolysin 药物治疗　出处：《吉林大学》2014年硕士论文　论文类型：学位论文

【摘要】：目的：复习并总结周围神经病变的发病机制、临床表现及治疗方法。选取神经营养及神经保护药物Cerebrolysin治疗吉兰—巴雷综合征(GBS)，观察疗效，评定安全性。方法：选取我院收治的111例GBS患者，所有临床表现及辅助检查结果等均符合Asbury1990诊断标准。分为6组，分别为一般治疗组（a1、a2组），激素治疗组（b1、b2组），丙种球蛋白治疗组（c1、c2组），1为空白对照组，2为Cerebrolysin治疗实验组。一般治疗组仅给予常规神经营养药物，激素治疗组和丙球治疗组在应用常规神经营养药物的基础上，分别给予激素和丙球治疗。各治疗方案组内实验组给予含有20ml Cerebrolysin的250ml生理盐水，每日1次静点，对照组不给予Cerebrolysin，共10天。在治疗10天时及治疗后30天观察记录患者肌力评分及TCSS评分，治疗后30天复查肌电图，记录MCV和Amp。将结果进行统计学分析。结果：治疗10天时，患者在肌力评分、TCSS评分均未见显著性改变（P＞0.05）。疗程结束后30天，肌力恢复方面，除a组外，各治疗方案组治疗后30天以及治疗后30天与治疗前的差值实验组与对照组比较均有统计学差异（P＜0.05）；治疗后30天，各组患者的TCSS评分均有明显改善，且各治疗方案组内实验组TCSS评分显著低于对照组，具备统计学意义（P＜0.05）；神经电生理检查方面，治疗后30天各治疗方案组MCV和Amp均有改善，各治疗方案组内实验组与对照组MCV和Amp比较，存在显著的统计学差异（P0.05）。结论： Cerebrolysin有助于修复受损的周围神经，，对GBS患者的临床症状、体征、MCV和Amp等方面均有不同程度的改善。
[Abstract]:Objective: To review and summarize the pathogenesis, clinical manifestation and treatment of peripheral neuropathy. Select neurotrophic and neuroprotective drug Cerebrolysin to treat Guillain-Barre syndrome (GBSs). Observe curative effect and evaluate safety. Methods: 111 patients with GBS were selected. All the clinical manifestations and the results of auxiliary examination were in accordance with the diagnostic criteria of Asbury1990. They were divided into 6 groups: general treatment group (A-1). Group A _ 2, steroid treatment group, B _ (1) B _ (2) group, and gamma globulin group (C _ (1) C _ (2)) as blank control group. 2 the experimental group was treated with Cerebrolysin. The general treatment group was given only routine neurotrophic drugs, while the hormone treatment group and the C ball treatment group were treated on the basis of routine neurotrophic drugs. The experimental group was given 250ml saline containing 20ml Cerebrolysin once a day. The control group was not given Cerebrolysin for 10 days. The muscle strength score and TCSS score were recorded on the 10th day of treatment and 30 days after treatment, and the electromyography was rechecked 30 days after treatment. MCV and AMPC were recorded. The results were statistically analyzed. Results: After 10 days of treatment, there was no significant change in the muscle strength score and TCSS score (P > 0.05). 30 days after the treatment, the muscle strength was recovered except in group A. The difference of 30 days after treatment, 30 days after treatment and 30 days after treatment in the experimental group and the control group were significantly different (P < 0.05). 30 days after treatment, the TCSS scores of the patients in each group were significantly improved, and the TCSS score in the experimental group was significantly lower than that in the control group (P < 0.05). The MCV and Amp of each treatment group were improved 30 days after treatment. The MCV and Amp of the experimental group were compared with those of the control group. There was significant statistical difference (P 0.05). Conclusion: Cerebrolysin is helpful to repair the injured peripheral nerve and improve the clinical symptoms, signs and Amp in patients with GBS.
【学位授予单位】：吉林大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R745.43

【参考文献】